Chapter 4: Q.4-29E (page 114)
Draw a stereoisomer of trans-1, 3-dimethylcyclobutane.
Short Answer
There is only one stereoisomer of trans-1, 3-dimethylcyclobutane.

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Chapter 4: Q.4-29E (page 114)
Draw a stereoisomer of trans-1, 3-dimethylcyclobutane.
There is only one stereoisomer of trans-1, 3-dimethylcyclobutane.

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In light of your answer to Problem 4-48, draw the two chair conformations of 1,1,3-trimethylcyclohexane and estimate the amount of strain energy in each. Which conformation is favored?
Draw two different chair conformations of trans-1,4 dimethylcyclohexane, and label all positions as axial or equatorial.
A 1, 2-cis disubstituted cyclohexane, such as cis-1, 2-dichlorocyclohexane, must have one group axial and one group equatorial. Explain.
Galactose, a sugar related to glucose, contains a six-membered ring in which all the substituents except the group, indicated below in red, are equatorial. Draw galactose in its more stable chair conformation.

Why do you suppose an axial cyano (–CN) substituent causes practically no 1,3-diaxial steric strain (0.4 kJ/mol)? Use molecular models to help with your answer.
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