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Chapter 26: Q 25. (page 1069)

What product is formed in the Suzuki coupling of A and B? This reaction was a key step in the synthesis of losartan, a drug used to treat hypertension.

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01

Suzuki reaction

Numerous coupling reactions are present, and Suzuki reactions are categorized as coupling reactions. Suzuki reactions are conducted with the help of palladium catalysts.

02

Lozartan

Another name for the medication Lozartan is Cozaar. It is consumed through the mouth and can cure several conditions such as blood pressure, heart failure, etc.

03

Product formed in the Suzuki coupling of A and B

Compound A, an organic halide, reacts with compound B, an organoborane in the presence of PdOAc2and NaOH, to give rise to the stereospecific product. The reaction can be given as follows.

Suzuki coupling of A and B

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Most popular questions from this chapter

Identify X, an intermediate that was converted to eletriptan (trade name Relpax), a drug used to treat migraines.

Draw the product formed from ring-closing metathesis of each compound.

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b.

Draw the product formed from the ring-closing metathesis of each compound. Then, devise a synthesis of each metathesis starting material from benzene, alcohols with less than five carbons, and any needed organic and inorganic reagents.

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What starting material is needed to prepare each compound by a ring-closing metathesis reaction?

Draw the products formed in each reaction.

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