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Chapter 26: Q 25. (page 1069)

What product is formed in the Suzuki coupling of A and B? This reaction was a key step in the synthesis of losartan, a drug used to treat hypertension.

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01

Suzuki reaction

Numerous coupling reactions are present, and Suzuki reactions are categorized as coupling reactions. Suzuki reactions are conducted with the help of palladium catalysts.

02

Lozartan

Another name for the medication Lozartan is Cozaar. It is consumed through the mouth and can cure several conditions such as blood pressure, heart failure, etc.

03

Product formed in the Suzuki coupling of A and B

Compound A, an organic halide, reacts with compound B, an organoborane in the presence of PdOAc2and NaOH, to give rise to the stereospecific product. The reaction can be given as follows.

Suzuki coupling of A and B

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Most popular questions from this chapter

Synthesize each product from the given starting materials using an organocuprate coupling reaction.

Draw the products formed when each alkene is treated with Grubbs catalyst.

a.

b.

c.

Draw the coupling product formed when each pair of compounds is treated with Pd(OAc)2, P(o-tolyl)3, and Et3N.

Draw the product of each coupling reaction.

a.

b.

c.

d.

Draw the product of each reaction.
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