91影视

Conjugate addition of a nucleophile in alpha,beta-unsaturated carbonyl compounds; ketone and aldehyde, happen in two ways:

• 1-2 conjugate addition
• 1,4 conjugate addition

In the Conjugate addition of nucleophile on thealpha,beta-unsaturated carbonyl compounds reaction forms the鈥渆nolate intermediate,鈥� which isresonance stabilized.

2-cyclohexanone undergoesconjugate nucleophile addition on its double bond, leading to the formation of resonance stabilized carbanion intermediate, which on protonation forms the keto nitrile that is the 3-oxocyclohexanecarbonitrile product.

The formation and structure of keto nitrile product (3-oxocyclohexanecarbonitrile) are shown as follows:

Formation of 3-oxocyclohexanecarbonitrile