91影视

Nucleophilic addition reaction on 鈥淎ldehydes and unhindered ketones鈥� with HCN results in the formation of cyanohydrins with the chemical formula (RCH(OH)C $鈮�$N).

Nucleophile addition of hydrogen cyanide (HCN) on carbonyl carbon is a 鈥渞eversible and base-catalyzed鈥漜hemical reaction.

The nucleophile addition of cyanide to the carbonyl group of ketone 2,2,6trimethylcyclohexanone is the reversible reaction; cyanohydrin formation is an equilibrium process.

2,2,6 trimethylcyclohexanone is sterically hindered by the presence of three methyl groups, making it difficult to attack the upcoming nucleophile cyanide $\left({\text{CN}}^{\text{-}}\right)$on the carbonyl carbon; therefore, the equilibrium of the reaction lies toward the side of unreacted ketone more than the product cyanohydrin.

The equilibrium favoured toward the unreacted ketone is shown as follows:

Formation of cyanohydrin not favoured