Chapter 29: Q6. (page 1158)
The enolate derived from diethyl acetamidomalonate is treated with each of the following alkyl halides. After hydrolysis and decarboxylation, what amino acid is formed?
Short Answer
(a)

(b)

(c)
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Chapter 29: Q6. (page 1158)
The enolate derived from diethyl acetamidomalonate is treated with each of the following alkyl halides. After hydrolysis and decarboxylation, what amino acid is formed?
(a)

(b)

(c)
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Question: For the tetra peptide Asp–Arg–Val–Tyr:
a. Name the peptide using one-letter abbreviations.
b. Draw the structure.
c. Label all amide bonds.
d. Label the N-terminal and C-terminal amino acids
What alkyl halide is needed to synthesize each amino acid from diethyl acetamidomalonate: (a)Asn; (b)His; (c)Trp?
Identify the lettered intermediates in the following reaction scheme. This is an alternative method to synthesize amino acids, based on the Gabriel synthesis of 1° amines (Section 25.7A).

Use the given experimental data to deduce the sequence of an octapeptide that contains the following amino acids: Ala, Gly (2 equiv), His (2 equiv), Ile, Leu and Phe. Edman degradation cleaves Gly from the octapeptide, and carboxypeptidase forms Leu and a heptapeptide. Partial hydrolysis forms the following fragments: Ile-His-Leu, Gly, Gly-Ala-Phe-His, and Phe-His-Ile.
Draw the organic products formed in the following reaction.

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