Chapter 25: PROBLEM 25.11 (page 1010)
What amine is formed by reduction of each amide?
a.
b.

c.

Short Answer
Answer
a.

b.

c.

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Chapter 25: PROBLEM 25.11 (page 1010)
What amine is formed by reduction of each amide?
a.
b.

c.

Answer
a.

b.

c.

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Question: Enalapril, a drug used to treat hypertension, is prepared from compounds D and E by reductive amination. What is the structure of enalapril?

Question: What starting materials are needed to prepare each drug using reductive amination? Give all possible pairs of compounds when more than one route is possible.
a.

b.

Question: Which nitrogen atom in each compound is more basic?
a.

b.

Rank the compounds in each group in order of increasing basicity.
(a)

(b)

Question: Rank the following compounds in order of increasing basicity and explain the order you chose.

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