Chapter 21: Q78E (page 726)
Assign structures to compounds with the following 1H NMR spectra:
(a)C5H9ClO2
IR:1735 cm-1
Short Answer
Thestructure of the compound using 1H NMR spectra can be drawn.
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Chapter 21: Q78E (page 726)
Assign structures to compounds with the following 1H NMR spectra:
(a)C5H9ClO2
IR:1735 cm-1
Thestructure of the compound using 1H NMR spectra can be drawn.
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Explain the observation that attempted Fischer esterification of 2,4,6-trimethyl benzoic acid with methanol and HCL is unsuccessful. No ester is obtained, and the acid is recovered unchanged. What alternative method of esterification might be successful?
21-49 Answer Problem 21-48 for reaction of the listed reagents with methylpropanoate.
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(a) The first step in trapping is the reaction of a hydroxyl group on the β -lactamase to open the β -lactam ring of tazobactam. Show the mechanism.
(b) The second step is opening the sulfur-containing ring in tazobactam to give an acyclic imine intermediate. Show the mechanism.
(c) Cyclization of the imine intermediate gives the trapped β-lactamase product. Show the mechanism.
21-69 We said in Section 21-6 that mechanistic studies on ester hydrolysishave been carried out using ethyl propanoate labeled with in theether-like oxygen. Assumethat labeled acetic acid is your onlysource of isotopic oxygen, and then propose a synthesis of the labeledethyl propanoate.
Write the mechanism of the reaction just shown between 3,4,5-trimethoxybenzoyl chloride and morpholine to form trimetozine. Use curved arrows to show the electron flow in each step.
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