Explanations 
Textbooks 
Flashcards 
91影视 AI 
Notes 
Study Plans 
Study Sets 
Find a degree 
Magazine Chapter 15: Q33P (page 712)
Problem:What acyl chloride and amine are required to synthesize the following amides?
a. N-ethylbutanamide b. N,N-dimethylbenzamide
Short Answer
Answer
a.
b.
Step by step solution
Acid chloride to amide
Amide is synthesized from the acid derivate, and themost reactive acid derivate is acid chloride.
The acid chloride reaction with the neutral amine (with at least one N-H group) is nucleophilic,attacking the carbonyl carbon of acid chloride to form atetrahedral intermediate,leaving chlorineformation of the desired amide.
Formation of N-ethylbutanamide
(acid chloride) reacts with the two moles of (amine) reaction goes by a nucleophilic addition-elimination mechanism.The nucleophile amine will attack the carbonyl carbon, leaving group (chloride). Finally, deprotonation forms the desired product, N-ethylbutanamide.
The reaction between the and the is shown below
Step 3: Formation of N,N-dimethylbenzamide
Acid chloride reacts with the two moles of (amine)reaction goes bya nucleophilic addition-elimination mechanism. The nucleophile amine will attack the carbonyl carbon, leaving group (chloride) leave, and finally, deprotonation forms the desired product, N,N-dimethylbenzamide.
The reaction between the and the is shown as follows.
Formation of N,N-dimethylbenzamide
Over 30 million students worldwide already upgrade their learning with 91影视!
