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Anorexia Nervosa (AN) is a psychiatric condition leading to substantial weight loss among women who are fearful of becoming fat. The article "Adipose Tissue Distribution After Weight Restoration and Weight Maintenance in Women with Anorexia Nervosa" (Amer. J. of ClinicalNutr., 2009: 1132-1137) used whole-body magnetic resonance imagery to determine various tissue characteristics for both an AN sample of individuals who had undergone acute weight restoration and maintained their weight for a year and a comparable (at the outset of the study) control sample. Here is summary data on intermuscular adipose tissue (IAT; kg).

Assume that both samples were selected from normal distributions.

a. Calculate an estimate for true average IAT under the described AN protocol, and do so in a way that conveys information about the reliability and precision of the estimation.

b. Calculate an estimate for the difference between true average AN IAT and true average control IAT, and do so in a way that conveys information about the reliability and precision of the estimation. What does your estimate suggest about true average AN IAT relative to true average control IAT?

Short Answer

Expert verified

(a) \(\;95\% \)confidence interval: \(({\bf{0}}.{\bf{38155}},)\)

(b) \(95\% \)confidence interval: \(( - 0.0045,0.3445)\)

The confidence interval suggest that there is no difference in the true average AN IAT compared to the true average control IAT.

Step by step solution

01

a)Step 1: Find the boundaries of confident intervals

Given:

\(\begin{array}{l}n = 16\\\bar x = 0.52\\s = 0.26\end{array}\)

Let us assume that we want to calculate the confidence interval with\(95\% \)confidence (other confidence levels work similarly).

\(c = 95\% = 0.95\)Determine the t-value by looking in the row starting with degrees of freedom\(df = n - 1 = 16 - 1 = 15\)and in the column with\(1 - c/2 = \)\(0.025\)in the table of the Student's T distribution:

\({t_\alpha } = 2.131\)

The margin of error is then:

\(E = {t_{\alpha /2}} \times \frac{s}{{\sqrt n }} = 2.13 \times \frac{{0.26}}{{\sqrt {16} }} \approx 0.13845\)

The boundaries of the confidence interval then become: \(\begin{array}{l}\bar x - E = 0.52 - 0.13845 = 0.38155\\\bar x + E = 0.52 + 0.13845 = 0.65845\end{array}\)

02

B)Step 2: find the end point of the confidence interval

\(\begin{array}{l}{{\bar x}_1} = 0.52\\{{\bar x}_2} = 0.35\\{n_1} = 16\\{n_2} = 8\\{s_1} = 0.26\\{s_2} = 0.15\end{array}\)

Let us assume that we want to calculate the confidence interval with\(95\% \)confidence (other confidence levels work sim

\(c = 95\% = 0.95\)

Determine the degrees of freedom (rounded down to the nearest integer): \(\Delta = \frac{{{{\left( {\frac{{s_1^2}}{{{n_1}}} + \frac{{s_2^2}}{{{n_2}}}} \right)}^2}}}{{\frac{{{{\left( {s_1^2/{n_1}} \right)}^2}}}{{{n_1} - 1}} + \frac{{{{\left( {s_2^2/{n_2}} \right)}^2}}}{{{n_2} - 1}}}} = \frac{{{{\left( {\frac{{{{0.26}^2}}}{{16}} + \frac{{{{0.15}^2}}}{8}} \right)}^2}}}{{\frac{{{{\left( {{{0.26}^2}/16} \right)}^2}}}{{16 - 1}} + \frac{{{{\left( {{{0.15}^2}/8} \right)}^2}}}{{8 - 1}}}} \approx 21\)

Determine the t-value by looking in the row starting with degrees of freedom \(df = 21\) and in the column with \(1 - c/2 = 0.025\) in the Student's \(t\) distribution table in the appendix:

\({t_{\alpha /2}} = 2.080\)

The margin of error is then:

\(E = {t_{\alpha /2}} \cdot \sqrt {\frac{{s_1^2}}{{{n_1}}} + \frac{{s_2^2}}{{{n_2}}}} = 2.080 \cdot \sqrt {\frac{{{{0.26}^2}}}{{16}} + \frac{{{{0.15}^2}}}{8}} \approx 0.1745\)

The endpoints of the confidence interval for\({\mu _1} - {\mu _2}\) are:

\(\begin{array}{l}\left( {{{\bar x}_1} - {{\bar x}_2}} \right) - E = (0.52 - 0.35) - 0.1745 = 0.17 - 0.1745 = - 0.0045\\\left( {{{\bar x}_1} - {{\bar x}_2}} \right) + E = (0.52 - 0.35) + 0.1745 = 0.172 + 0.1745 = 0.3445\end{array}\)

The confidence interval suggest that there is no difference in the true average AN IAT compared to the true average control IAT, because the confidence interval contains \(0\)

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Most popular questions from this chapter

Using the traditional formula, a \(95\% \) CI for \({p_1} - {p_2}\)is to be constructed based on equal sample sizes from the two populations. For what value of \(n( = m)\)will the resulting interval have a width at most of .1, irrespective of the results of the sampling?

Return to the data on maximum lean angle given in Exercise 28 of this chapter. Carry out a test at significance level .10 to see whether the population standard deviations for the two age groups are different (normal probability plots support the necessary normality assumption).

The article "Fatigue Testing of Condoms" cited in Exercise 7.32 reported that for a sample of 20 natural latex condoms of a certain type, the sample mean and sample standard deviation of the number of cycles to break were 4358 and 2218 , respectively, whereas a sample of 20 polyisoprene condoms gave a sample mean and sample standard deviation of 5805 and 3990 , respectively. Is there strong evidence for concluding that true average number of cycles to break for the polyisoprene condom exceeds that for the natural latex condom by more than 1000 cycles? Carry out a test using a significance level of 01 . (Note: The cited paper reported P-values of t tests for comparing means of the various types considered.)

An experimenter wishes to obtain a CI for the difference between true average breaking strength for cables manufactured by company I and by company II. Suppose breaking strength is normally distributed for both types of cable with s1 5 30 psi and s2 5 20 psi.

  1. If costs dictate that the sample size for the type I cable should be three times the sample size for the type II cable, how many observations are required if the 99% CI is to be no wider than 20 psi?
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Arsenic is a known carcinogen and poison. The standard laboratory procedures for measuring arsenic \(concentration (\mu g/L)\) in water are expensive. Consider the accompanying summary data and Minitab output for comparing a laboratory method to a new relatively quick and inexpensive field method (from the article "Evaluation of a New Field Measurement Method for Arsenic in Drinking Water Samples," J. of Emvir. Engr., 2008: 382-388).

Two-Sample T-Test and CI

Sample N Mean StDev SE Mean

1 3 19.70 1.10 0.65

2 3 10.90 0.60 0.35

Estimate for difference: 8.800

95% CI for difference: 6.498,11.102

T -Test of difference =0 (vs not = ):

T -Value =12.1 P -Value =0.001 DF=3

What conclusion do you draw about the two methods, and why? Interpret the given confidence interval. (Note: One of the article's authors indicated in private communication that they were unsure why the two methods disagreed.)

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