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In an experiment to study the way in which different anesthetics affect plasma epinephrine concentration, ten dogs were selected and concentration was measured while they were under the influence of the anesthetics isoflurane, halothane, and cyclopropane (鈥淪ympathoadrenal and Hemodynamic Effects of Isoflurane, Halothane, and Cyclopropane in Dogs,鈥 Anesthesiology, 1974: 465鈥470). Test at level .05 to see whether there is an anesthetic effect on concentration

Short Answer

Expert verified

Do not reject null hypothesis

Step by step solution

01

Friedman’s test:

The Friedman鈥檚 test for rendomized block experiment

Test for teststatistic is

\(\begin{array}{l}{F_r} = \frac{{12J}}{{I\left( {I + 1} \right)}}\sum\limits_{i = 1}^I {{{\left( {{{\bar R}_i} - \frac{{I + 1}}{2}} \right)}^2}} \\ = \frac{{12J}}{{IJ\left( {I + 1} \right)}}\sum\limits_{i = 1}^I {\bar R_i^2 - 3J} \left( {I + 1} \right)\end{array}\)

When the null hypothesis is true test statistic \({F_r}\), has approximately chi-squared distribution with I-1 degrees of freedom.

02

solving further:

Two table goes together- point\({x_{ij}}\)in the first table corresponds to the\({r_{ij}}\)rank in the second table.

i

Blocks

Isoflurane

0.28

0.51

1

0.39

0.29

0.36

0.32

0.69

0.17

0.33

Halothane

0.3

0.39

0.63

0.38

0.21

0.88

0.39

0.51

0.32

0.42

Cyclopropane

1.07

1.35

0.69

0.28

1.24

1.53

0.49

0.56

1.02

0.3

i

Ranks

\({r_i}\)

\(r_i^2\)

1

2

3

4

5

6

7

8

9

10

Isoflurane

1

2

3

3

2

1

1

3

1

2

19

361

Halothane

2

1

1

2

1

2

2

1

2

3

17

289

Cyclopropane

3

3

2

1

3

3

3

2

3

1

24

576

03

testing static value:

The test statistic value is,

\(\begin{array}{l}{f_r} = \frac{{12J}}{{I\left( {I + 1} \right)}}{\sum\limits_{i = 1}^I {\left( {{{\bar R}_i} - \frac{{I - 1}}{2}} \right)} ^2}\\ = \frac{{12}}{{IJ\left( {I + 1} \right)}}\sum\limits_{i = 1}^I {\bar R_i^2} - 3J\left( {I + 1} \right)\\ = \frac{{12}}{{10 \cdot 3 \cdot 4}} \cdot \left( {361 + 289 + 576} \right) - 3 \cdot 10 \cdot 4\\ = 2.60\end{array}\)

Degrees of freedom are

\(df = I - 1 = 3 - 1 = 2\)

Critical value at significant level 0.05 is


\(\begin{array}{l}X_{0.05,2}^2 = 5.99\\X_{0.05,2}^2 = 5.99 > 2.60 = {f_r}\end{array}\)

Do not reject null hypothesis

Hence, do not reject null hypothesis.

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