Chapter 18: 6P (page 684)
What acid chloride would be needed to prepare each of the following ketones from benzene using a Friedel–Crafts acylation?

Short Answer

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Chapter 18: 6P (page 684)
What acid chloride would be needed to prepare each of the following ketones from benzene using a Friedel–Crafts acylation?


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Draw the structure of A, an intermediate in the synthesis of the antipsychotic drug risperidone. Explain why three rings in risperidone are considered aromatic.

Devise a synthesis of each compound from the indicated starting material.

Which of the following compounds undergo Friedel–Crafts alkylation with and ? Draw the products formed when a reaction occurs.


Draw the products formed when each compound is treated with and .


Rank the following compounds in order of increasing reactivity in electrophilic aromatic substitution.

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