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Chapter 23: Q22P (page 1092)

Question: What is the source of the methyl group in thymidine?

Short Answer

Expert verified

The primary source of methyl group in thymidine is from N5, N10-methylene-THF. Tetrahydrofolate is a co-enzyme required by enzyme catalyzed reactions.

Step by step solution

01

The structure of N5, N10-methylene-THF

It is one of the co-enzyme of tetrahydrofolate transfers its methylene group to their substrates.

02

Source of methyl group in thymidine

Thymidine is derived by the addition of hydride ion from N5, N10-methylene-THF to uracil base. Thus,methyl group in thymidine is comes from the coenzyme N5, N10-methylene-THF. The methylene group of N5, N10-methylene-THF comes from the CH2OH group of serine by means of a PLP catalyzed bond cleavage.

Thus, source of methylene group in thymidine base is explained.

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Most popular questions from this chapter

Question:Five coenzymes are required by -ketoglutarate dehydrogenase, the enzyme in the citric acid cycle that converts -ketoglutarate to succinyl-CoA.

a. Identify the coenzymes.

b.Propose a mechanism for the reaction.

Question:Thiols such as ethanethiol and propanethiol can be used to reduce vitamin K epoxide to vitamin KH2, but they react much more slowly than dihydrolipoate. Explain why this is so.

Explain why the ability of PLP to catalyze an amino acid transformation is greatly reduced if a PLP- requiring enzymatic reaction is carried out at a pH at which the pyridine nitrogen is not protonated.

Question: Name the coenzymes that

a. allow electrons to be delocalized.

b. are oxidizing agents.

c. provide a strong base.

d.donate one-carbon groups

How many conjugated double bonds are there in

a. FAD?

b. FADH2
See all solutions

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