Chapter 17: Q63P (page 848)
Show how the following compounds can be prepared from cyclohexanone:

Short Answer
The answer is,

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Chapter 17: Q63P (page 848)
Show how the following compounds can be prepared from cyclohexanone:

The answer is,

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Draw the product of the reaction of each of the following compounds with a base:

The Reformatsky reaction is an addition reaction in which an organozinc reagent is used instead of a Grignard reagent to add to the carbonyl group of an aldehyde or a ketone. Because the organozinc reagent is less reactive than a Grignard reagent, a nucleophilic addition to the ester group does not occur. The organozinc reagent is prepared by treating an ß-bromo ester with zinc.
Describe how each of the following compounds can be prepared, using a Reformatsky reaction:
How many ways can you recall to synthesize
a. an ether? b. an aldehyde? c. an alkene? d. an amine?
A ketone undergoes acid-catalyzed bromination, acid-catalyzed chlorination, racemization, and acid-catalyzed deuterium exchange at the -carbon. All of these reactions have similar rate constants. What does this tell you about the mechanisms of these reactions?
An aldol addition can be catalyzed by acids as well as by bases. Propose a mechanism for the acid-catalyzedaldol addition of propanal.
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