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Chapter 18: 44 P (page 722)

D is an intermediate in the synthesis of rosiglitazone (trade name Avandia), a drug used for type 2 diabetes. Suggest two different methods to prepare the ether in D by substitution reactions.

Short Answer

Expert verified

The intermediate D can be synthesized using the given methods:

i. Williamson鈥檚 ether synthesis

Step by step solution

01

Intermediate

The transient species formed during the conversion of reactants to products is termed intermediate.

The intermediate is short-lived and has more energy than the reactants and products.

02

Williamson’s ether synthesis

The reaction of an alcohol with an alkyl halide in the presence of a base yields an ether R-O-R'R,R'=alkyl/arylgroups. This reaction is named Williamson鈥檚 ether synthesis.

03

Synthesis of the intermediate D

The methods that can be used to synthesize D are given below.

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