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Pristanal (see Problem 20-33) can be oxidized to pristanate. Can this compound be further degraded by β oxidation and, if so, what are the reaction products?

Short Answer

Expert verified

Propionyl-CoA would be the primary product.

Step by step solution

01

Definition of β oxidation

The metabolic process by which activated fatty acids are broken down in a sequence of steps to form acetyl-CoA, which subsequently enters the citric acid cycle, is known as β oxidation.

02

Step 2: Oxidized form of pristanal-pristanate

The oxidised form of pristanal-pristanate is as follows:

03

Degradation of pristanate

In the liver, pristanate (the conjugate base of pristanic acid, which is transformed to pristanoyl-CoA) can be degraded to propionyl-CoA by β oxidation.The reactions that occur during the first cycle of βoxidation are listed below.

1.Acyl-CoA oxidase reaction:

Pristanoyl-COA+FAD→2,3-pristenoyl-COA+FADH2

2.2-enoyl-CoA hydratase reaction:

2,3-pristenoyl-COA→3-hydroxyoristanoyl-CoA

3.3-hydroxyacyl-CoA dehydrogenase reaction:3-hydroxyoristanoyl-COA+NAD+→3-ketopristanoyl-COA+NADH+H+

4.3-ketoacyl-CoA thiolase reaction:

3-ketopristanoyl-CoA+CoASH→4,8,12-trimethyltridecanoyl-COA+propionyl-CoA

Hence, propionyl-CoA would be the primary product.

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