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The tricarboxylate transport system supplies cytosolic acetyl-CoA for palmitate synthesis. What percentage of the NADPH required for palmitate synthesis is thereby provided?

Short Answer

Expert verified

57%of NADPH is required for palmitate production.

Step by step solution

01

Definition of Palmitic

Palmitic acid is a C16 saturated fatty acid that passes through a number of steps in the β oxidation process to produce acetyl-CoA. In order to generate enough ATP, acetyl-CoA is then utilised in the citric acid cycle.

02

Conjugation of palmitic acid 

Palmitate is a conjugate base of palmitic acid that is synthesised using 14 NADPH.

To oxidise the palmitic acid, it must go through seven rounds of oxidation, yielding a total of eight acetyl-CoA.

03

Work of the tricarboxylate transport system

The tricarboxylate transport system transports8acetyl-CoA back to the cytosol, resulting in a total of8NADPH. This represents that,

PercentageofNADPHsupplied=±·³Ü³¾²ú±ð°ù´Ç´Ú±·´¡¶Ù±Ê±á p°ù´Ç±¹¾±»å±ð»å²ú²â³Ù°ù¾±³¦²¹°ù²ú´Ç³æ²â±ô²¹³Ù±ð³Ù°ù²¹²Ô²õ±è´Ç°ù³Ù²õ²â²õ³Ù±ð³¾°Õ´Ç³Ù²¹±ô²Ô³Ü³¾²ú±ð°ù´Ç´Ú±·´¡¶Ù±Ê±á r±ð±ç³Ü¾±°ù±ð»å´Ú´Ç°ù p²¹±ô³¾¾±³Ù²¹³Ù±ð²õ²â²Ô³Ù³ó±ð²õ¾±²õ×100

So using the formula and substituting the values, we get,

8/14=0.57(57%)(normal percentage formula is used) of the NADPH required for palmitate production.

Hence, the palmitate requires57% of the NADPH at the time of production

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