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Automatic identification of the boundaries of significant structures within a medical image is an area of ongoing research. The paper 鈥淎utomatic Segmentation of Medical Images Using Image Registration: Diagnostic and

Simulation Applications鈥 (J. of Medical Engr. and Tech., 2005: 53鈥63)discussed a new technique for such identification. A measure of the accuracy of the automatic region is the average linear displacement (ALD). The paper gave the following ALD observations for a sample of 49 kidneys (units of pixel dimensions).

1.38 0.44 1.09 0.75 0.66 1.28 0.51

0.39 0.70 0.46 0.54 0.83 0.58 0.64

1.30 0.57 0.43 0.62 1.00 1.05 0.82

1.10 0.65 0.99 0.56 0.56 0.64 0.45

0.82 1.06 0.41 0.58 0.66 0.54 0.83

0.59 0.51 1.04 0.85 0.45 0.52 0.58

1.11 0.34 1.25 0.38 1.44 1.28 0.51

a.Summarize/describe the data.

b.Is it plausible that ALD is at least approximately normally distributed? Must normality be assumed prior to calculating a CI for true average ALD or testing hypotheses about true average ALD? Explain.

c.The authors commented that in most cases the ALD is better than or of the order of 1.0. Does the data in fact provide strong evidence for concluding that true average ALD under these circumstances is less than 1.0? Carry out an appropriate test of hypotheses.

d.Calculate an upper confidence bound for true average ALD using a confidence level of 95%, and interpret this bound.

Short Answer

Expert verified

a)The distribution is skewed to the right (or positively skewed).

b)The normal probability plot contains strong curvature and thus it is not plausible that ALD is at least approximately normal distribution.

c)There is sufficient evidence to support the claim that the true average ALD under these circumstances is less than \(1.0\).

d) The upper confidence bound for the true average ALD is \(0.8209\).

Step by step solution

01

Step 1:Null hypothesis

The null hypothesis, denoted by H0, is the claim that is initially assumed to be true (the 鈥減rior belief鈥 claim). The alternative hypothesis, denoted by Ha, is the assertion that is contradictory to H0.

The null hypothesis will be rejected in favour of the alternative hypothesis only if sample evidence suggests that H0 is false. If the sample does not strongly contradict H0, we will continue to believe in the plausibility of the null hypothesis. The two possible conclusions from a hypothesis-testing analysis are then reject H0 or fail to reject H0.

02

Solution for part a).

Given that,

\(n = 49\)

The mean is the sum of all values divided by the number of values:

\(\begin{array}{l}\overline x = \frac{{1.38 + 0.44 + 1.09 + .... + 1.44 + 1.28 + 0.51}}{{49}}\\ = \frac{{36.74}}{{49}}\\ \approx 0.749\end{array}\)

The variance is the sum of squares deviations from the mean divided by \(n - 1\). The standard deviation i the square root of the variance:

\(\begin{array}{l}s = \sqrt {\frac{{{{(1.38 - 0.7498)}^2} + .... + {{(0.51 - 0.7498)}^2}}}{{49 - 1}}} \\s \approx 0.3025\end{array}\)

03

Box plot:

The whiskers of the box plot are at the minimum and maximum value. The box starts at the first quartile, ends at the third quartile and has a vertical line at the median.

The first quartile is at \(25\% \) of the sorted data list, the median at \(50\% \) and the third quartile at \(75\% \).

The figure also contains the most commonly used descriptive measures (such as the mean, median, standard deviation, etc.).

The distribution is skewed to the right (or positively skewed), because the box in the box plot lies to the left between the whiskers and the vertical line of the median in the box of the box plot also lies to the left in the box.

04

Normal probability plot.

The data values are on the horizontal axis and the standardized normal scores are on the vertical axis.

If the data contains \(n\)data values, then the standardized normal scores are the z-scores in the normal probability table of the appendix corresponding to an area of \(\frac{{j - 0.5}}{n}\)(or the closest area) with \(j \in \{ 1,2,3,...,n\} \).

The smallest standardized score corresponds with the smallest data value, the second smallest standardized score corresponds with the second smallest data value, and so on.

05

 Step 5: Solution for part b).

If the pattern in the normal probability plot is roughly linear and does not contain strong curvature, then the distribution is approximately normal.

The normal probability plot contains strong curvature and thus it is not plausible that ALD is at least approximately normal distribution.

It is not necessary to assume normality, because the sample is large and the central limit theorem then tells us that the sampling distribution of the sample mean is approximately normal (thus we are capable of calculating a confidence interval without making assumptions).

06

Solution for part c).

Let us assume : \(\alpha = 0.05\)

Given claim: Average is less than \(1.0\).

The null hypothesis states that the population mean is equal to the value mentioned in the claim:

\({H_0}:\mu = 1.0\)

The alternative hypothesis states the claim:

\({H_a}:\mu < 1.0\)

Since the sample is large, we can use the z-test.

The sampling distribution of the sample mean \(\overline x \) has mean \(\mu \)and standard deviation \(\frac{\sigma }{{\sqrt n }}\).

The z-core is the value decreased by the mean, divided by the standard deviation:

\(z = \frac{{\overline x - \mu }}{{\sigma /\sqrt n }}\)

\(\begin{array}{l}z = \frac{{0.7498 - 1.0}}{{0.3025/\sqrt {49} }}\\z \approx - 5.79\end{array}\)

07

Hypothesis is reject or not.

The P-value is the probability of obtaining a value more extreme or equal to the standard deviation test statistic z, assuming that the null hypothesis is true. Determine the probability table in the appendix.

\(\begin{array}{l}P = P(Z < - 5.79)\\ \approx 0\end{array}\)

The \(P\)-value is smaller than the significance level \(\alpha \),then the null hypothesis is rejected.

\(P < 0.05\)\( \Rightarrow \)Reject \({H_0}\)

There is sufficient evidence to support the claim that the true average ALD under these circumstances is less than \(1.0\).

08

Solution for part d).

Given that,

\(\begin{array}{l}c = 95\% \\c = 0.95\end{array}\)

Since the sample is large, we can use the confidence interval using the standard normal distribution.

For confidence level \(1 - \alpha = 0.95\) determine \({z_\alpha } = {z_{0.05}}\)using the normal probability table in the appendix(look up \(0.05\) in the table, the z-score is then the found z-score with opposite sign):

\({z_{\alpha /2}} = 1.645\)

09

Solution for part d).

Now we take the average of \(1.64\) and \(1.65\), because \(0.05\) lies exactly in the middle between \(0.0495\) and \(0.0505\)

The margin of error is then:

\(\begin{array}{l}E = {z_{\alpha /2}}\frac{\sigma }{{\sqrt n }}\\ = 1.645\left( {\frac{{0.3025}}{{\sqrt {49} }}} \right)\\ \approx 0.0711\end{array}\)

The boundaries of the confidence interval then become:

\(\begin{array}{l}\overline x + E = 0.7498 + 0.0711\\ = 0.8209\end{array}\)

Thus, The upper confidence bound for the true average ALD is \(0.8209\).

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