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Antipsychotic drugs are widely prescribed for conditions such as schizophrenia and bipolar disease. The article "Cardiometabolic Risk of SecondGeneration Antipsychotic Medications During First-Time Use in Children and Adolescents"\((J\). of the Amer. Med. Assoc., 2009) reported on body composition and metabolic changes for individuals who had taken various antipsychotic drugs for short periods of time.

a. The sample of 41 individuals who had taken aripiprazole had a mean change in total cholesterol (mg/dL) of\(3.75\), and the estimated standard error\({s_D}/\sqrt n \)was\(3.878\). Calculate a confidence interval with confidence level approximately\(95\% \)for the true average increase in total cholesterol under these circumstances (the cited article included this CI).

b. The article also reported that for a sample of 36 individuals who had taken quetiapine, the sample mean cholesterol level change and estimated standard error were\(9.05\)and\(4.256\), respectively. Making any necessary assumptions about the distribution of change in cholesterol level, does the choice of significance level impact your conclusion as to whether true average cholesterol level increases? Explain. (Note: The article included a\(P\)-value.)

c. For the sample of 45 individuals who had taken olanzapine, the article reported\(99\% CI\)as a\(95\% \)CI for true average weight gain\((kg)\). What is a $\(99\% CI\)?

Short Answer

Expert verified

(a) \(( - 4.087438,11.587438)\)

(b) There is sufficient evidence to support the claim that the true average cholesterol level increases at the \(0.05\) significance level.

The choice of significance level impacts your conclusion.

(c) \((6.9897,10.0803)\)

Step by step solution

01

A)Step 1: Find the endpoint of confidence interval

Given:

\(\begin{array}{l}\bar d = 3.75\\{s_d}/\sqrt n = 3.878\\n = 41\\c = 95\% = 0.95\end{array}\)

Determine the\({t_{\alpha /2}}\) using the Student's T distribution table in the appendix with \(df = n - 1 = 41 - 1 = 40\) :

\({t_{0.025}} = 2.021\)

The margin of error is then:

\(E = {t_{\alpha /2}} \cdot \frac{{{s_d}}}{{\sqrt n }} = 2.021 \cdot 3.878 = 7.837438\)

The endpoints of the confidence interval for d are:

\(\begin{array}{l}\bar d - E = 3.75 - 7.837438 = - 4.087438\\\bar d + E = 3.75 + 7.837438 = 11.587438\end{array}\)

02

b)Step 2: Find the value of test statistic

Given:

\(\begin{array}{l}\bar d = 9.05\\{s_d}/\sqrt n = 4.256\\n = 36\end{array}\)

Let us assume:

\(\alpha = 0.05\)

Given claim: increases

The claim is either the null hypothesis or the alternative hypothesis. The null hypothesis and the alternative hypothesis state the opposite of each other. The null hypothesis needs to contain the value mentioned in the claim.

\(\begin{array}{l}{H_0}:{\mu _d} = 0\\{H_a}:{\mu _d} > 0\end{array}\)

Determine the value of the test statistic:

\(t = \frac{{\bar d - d}}{{{s_d}/\sqrt n }} = \frac{{9.05 - 0}}{{4.256}} \approx 2.126\)

The P-value is the probability of obtaining the value of the test statistic, or a value more extreme, assuming that the null hypothesis is true. The Pvalue is the number (or interval) in the column title of the Student's T distribution in the appendix containing the t-value in the row\(d{\bf{f}} = {\bf{n}} - {\bf{1}} = \)\(36 - 1 = 35 > 34\) :

\(0.01 < P < 0.025\)

If the P-value is less than the significance level, reject the null hypothesis.

\(P < 0.05 \Rightarrow {\mathop{\rm Reject}\nolimits} {H_0}\)

There is sufficient evidence to support the claim that the true average cholesterol level increases at the \(0.05\) significance level.

The choice of significance level impacts your conclusion, because you will make a different conclusion at the \(0.01\) significance level.

03

C)Step 3: Find the margin of error

\(\begin{array}{l}c = 99\% = 99\\n = 45\end{array}\)

\(95\% \)confidence interval: \((7.38,9.69)\)

The sample mean is the center of the confidence interval and thus is the average of the boundaries of the confidence interval:

\(\bar d = \frac{{7.38 + 9.69}}{2} = 8.535\)

Determine the \({t_{\alpha /2}}\) using the Student's T distribution table in the appendix with\(df = n - 1 = 45 - 1 = 44 > 40\):

\({t_{0.025}} = 2.021\)

The margin of error is given by the formula:

\(E = {t_{\alpha /2}} \cdot \frac{{{s_d}}}{{\sqrt n }}\)

The margin of error is half the width of the confidence interval:

\(\frac{{9.69 - 7.38}}{2} = 2.021 \cdot \frac{{{s_d}}}{{\sqrt {45} }}\)

Divide each side by \(2.021/\sqrt {45} \) :

\({s_d} = \frac{{(9.69 - 7.38)\sqrt {45} }}{{2(2.021)}} \approx 3.8337\)

04

Find the end point of the confidence interval

Determine the\({t_{\alpha /2}}\)using the Student's T distribution table in the appendix with\(df = n - 1 = 45 - 1 = 44 > 40\):

\({t_{0.005}} = 2.704\)

The margin of error is then:

\(E = {t_{\alpha /2}} \cdot \frac{{{s_d}}}{{\sqrt n }} = 2.704 \cdot \frac{{3.8337}}{{\sqrt {45} }} = 1.5453\)

The endpoints of the confidence interval for\({\mu _d}\)are:

\(\begin{array}{l}\bar d - E = 8.535 - 1.5453 = 6.9897\\\bar d + E = 8.535 + 1.5453 = 10.0803\end{array}\)

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