Chapter 23: Q2P (page 1069)
What are the products of the following reaction?

Short Answer

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Chapter 23: Q2P (page 1069)
What are the products of the following reaction?


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Acetolactatesynthasetransfers the acyl group of pyruvate to \(\alpha \)-ketobutyrate. This is the first step in the biosynthesis of the amino acid isoleucine. Propose a mechanism for this reaction.

Question:Five coenzymes are required by -ketoglutarate dehydrogenase, the enzyme in the citric acid cycle that converts -ketoglutarate to succinyl-CoA.
a. Identify the coenzymes.
b.Propose a mechanism for the reaction.
Explain why the hydrogens of the C-8 methyl group are more acidic than those of the C-7 methyl group.
Question:When UMP is dissolved in T2O, exchange of T for H occurs at the 5-position. Propose a mechanism for this exchange.
\(\alpha \)-Keto acids other than \(\alpha \) -ketoglutarate can accept the amino group from pyridoxamine in enzyme catalyzed transamination reactions. What amino acids are formed when the following a-keto acids accept the amino group?

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