Chapter 18: 35 P (page 721)
What is the major product formed by an intramolecular Friedel–Crafts acylation of the following compound?

Short Answer
The major product formed is as follows:

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Chapter 18: 35 P (page 721)
What is the major product formed by an intramolecular Friedel–Crafts acylation of the following compound?

The major product formed is as follows:

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Draw the products of each reaction.

Draw the products of each reaction.


For each N-substituted benzene, predict whether the compound reacts faster than, slower than, or at a similar rate to benzene in electrophilic aromatic substitution. Then draw the major product (s) formed when each compound reacts with a general electrophile .

Question: Ibufenac, a para-disubstituted arene with the structure HO2CCH2C6H4CH2CH(CH3)2, is a much more potent analgesic than aspirin, but it was never sold commercially because it caused liver toxicity in some clinical trials. Devise a synthesis of ibufenac from benzene and organic halides having fewer than five carbons.
Draw the products formed when A and B are treated with each of the following reagents:
(a),; (b)l3; (c)

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