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Chapter 7: Q7P (page 219)

Is the P50 higher or lower than normal in (a) hemoglobin Yakima and (b) hemoglobin Kansas? Explain.

Short Answer

Expert verified

The P50 value is lower than normal in (a) hemoglobin Yakima and higher than normal in (b) hemoglobin Kansas.

Step by step solution

01

Hemoglobin Yakima

In the hemoglobin variant Yakima, the amino acid Asp (99) is mutated to His. This mutation disrupts a hydrogen bond that stabilizes the T conformation of hemoglobin.

T conformation of hemoglobin represents the deoxyhemoglobin state. Hence, stabilizing the deoxy-conformation represents a reduction in the oxygen affinity of hemoglobin. Thus, the P50 value of the variant becomes lower than normal.

02

Hemoglobin Kansas

In the hemoglobin variant Kansas, the amino acid Asn (99) is mutated to Thr. This mutation disrupts a hydrogen bond that stabilizes the R conformation of hemoglobin.

R conformation of hemoglobin represents the oxyhemoglobin state. Hence, stabilizing the oxy-conformation represents an increase in the oxygen affinity of hemoglobin. Thus, the P50 value of the variant becomes higher than normal.

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