Q4P Calculate the p50 value for hemo... [FREE SOLUTION]

91影视

Chapter 7: Q4P (page 218)

Calculate the p₅₀ value for hemoglobin if Yo₂ = 0.82 when pO₂ = 25 torr.

Short Answer

Expert verified

The p₅₀ value for hemoglobin if Yo₂ = 0.82 when pO₂ = 25 torr is 17.11 torr.

Step by step solution

Equation for the p50 value

To determine the p₅₀ of hemoglobin, Hill equation is used, which is as follows:

$Y_{O_{2}} = \frac{{(p O_{2})}^{n}}{{(p_{50})}^{n} + {(p O_{2})}^{n}}$

Here,is the fractional saturation= 0.82; p₅₀ is the oxygen pressure where hemoglobin is half saturated, which is to be determined; pO₂ is the partial pressure of oxygen = 25 torr; n is the Hill constant of hemoglobin = 4.

Derivation of the Hill equation

From the above equation, we could be able to construct an equation for p₅₀.

$\begin{array}{rcl} Y_{O_{2}} & = & \frac{{(p O_{2})}^{n}}{{(p_{50})}^{n} + {(p O_{2})}^{n}} \\ Y_{O_{2}} * {(p_{50})}^{n} + Y_{O_{2}} * {(p O_{2})}^{n} & = & {(p O_{2})}^{n} \\ Y_{O_{2}} * {(p_{50})}^{n} & = & {(p O_{2})}^{n} - Y_{O_{2}} * {(p O_{2})}^{n} \\ {(p_{50})}^{n} & = & \frac{{(p O_{2})}^{n} - Y_{O_{2}} * {(p O_{2})}^{n}}{Y_{O_{2}}} \\ {(p_{50})}^{n} & = & \frac{{(p O_{2})}^{n} - (1 - Y_{O_{2}})}{Y_{O_{2}}} \end{array}$

Determination of p50 value

Putting all the values in the above equation, we get,

$\begin{array}{rcl} {(p_{50})}^{4} & = & \frac{{(25)}^{4} (1 - 0.82)}{0.82} \\ {(p_{50})}^{4} & = & \frac{390625 * 0.18}{0.82} \\ {(p_{50})}^{4} & = & 85747 \\ p_{50} & = & {(85747)}^{\frac{1}{4}} \\ p_{50} & = & 17.11 t o r r \end{array}$

Hence, the value of p₅₀ is 17.11 torr

Unlock Step-by-Step Solutions & Ace Your Exams!

Full Textbook Solutions
Get detailed explanations and key concepts
Unlimited Al creation
Al flashcards, explanations, exams and more...
Ads-free access
To over 500 millions flashcards
Money-back guarantee
We refund you if you fail your exam.

Over 30 million students worldwide already upgrade their learning with 91影视!

One App. One Place for Learning.

All the tools & learning materials you need for study success - in one app.

Get started for free

Recommended explanations on Biology Textbooks

View all explanations

What do you think about this solution?

We value your feedback to improve our textbook solutions.

[Ligand] (mM)	Y
0.1	0.3
0.2	0.5
0.4	0.7
0.7	0.9

[Ligand] (mM)	Y
0.2	0.1
0.3	0.3
0.4	0.6
0.6	0.8

91影视

Calculate the p₅₀ value for hemoglobin if Yo₂ = 0.82 when pO₂ = 25 torr.

Short Answer

Step by step solution

Equation for the p50 value

Derivation of the Hill equation

Determination of p50 value

One App. One Place for Learning.

Most popular questions from this chapter

Recommended explanations on Biology Textbooks

Biological Structures

Microbiology

Cell Communication

Reproduction

Cellular Energetics

Biological Processes

Study anywhere. Anytime. Across all devices.

91影视

Calculate the p50 value for hemoglobin if Yo2 = 0.82 when pO2 = 25 torr.

Short Answer

Step by step solution

Equation for the p50 value

Derivation of the Hill equation

Determination of p50 value

One App. One Place for Learning.

Most popular questions from this chapter

Recommended explanations on Biology Textbooks

Biological Structures

Microbiology

Cell Communication

Reproduction

Cellular Energetics

Biological Processes

Study anywhere. Anytime. Across all devices.

Calculate the p₅₀ value for hemoglobin if Yo₂ = 0.82 when pO₂ = 25 torr.