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Chapter 23: Q15P (page 829)

Is trimethoprim a mechanism-based inhibitor of bacterial dihydrofolate reductase?

Short Answer

Expert verified

Trimethoprim is not a mechanism-based inhibitor of bacterial DHFR because it is a reversible inhibitor.

Step by step solution

01

Trimethoprim

Trimethoprim is an antifolate, a substance that prevents folate cofactors from working properly.It binds to dihydrofolate reductase (DHFR) and inhibits its activity.

02

Trimethoprim is a mechanism-based inhibitor of bacterial dihydrofolate reductase or not

The irreversible inhibition of enzymes by substrate analogs is known as mechanism-based inhibition in biochemistry. As trimethoprim is a reversible inhibitor, it can be said to be a mechanism-based inhibitor of bacterial DHFR.

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