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Chapter 23: Q1CP (page 808)

List the starting materials and cofactors required for IMP biosynthesis.

Short Answer

Expert verified

The starting material -D-ribose-5-phosphate, and eleven cofactors are used in the biosynthesis of inosine monophosphate (IMP).

Step by step solution

01

Starting materials required for the biosynthesis of inosine monophosphate (IMP).

The inosine monophosphate (IMP) is the purine derivative of the base hypoxanthine. The starting material of the inosine monophosphate (IMP) is -D-ribose-5-phosphate.

02

Cofactors.

The cofactors are non-protein compounds. They play the role of an enzyme as a catalyst and increase the reaction rate.

03

Cofactors required for the biosynthesis of inosine monophosphate (IMP).

  1. Ribose phosphate pyrophosphokinase.
  2. Amidophosphoribosyl transferase.
  3. Glycinamide ribotide (GAR) synthetase.
  4. Glycinamide ribotide (GAR) transformylase.
  5. Formylglycinamidine ribotide (FGAM) synthetase.
  6. 5-Aminoimidazole ribotide (AIR) synthetase.
  7. 5-Aminoimidazole ribotide (AIR) carboxylase.
  8. 5-Aminoimidazole-4-(N-succinylocarboxamide) ribotide (SAICAR) synthetase.
  9. Adenylosuccinate lyase.
  10. 5-Aminoimidazole-4-carboxamide ribotide (AICAR) transformylase.
  11. Inosine monophosphate (IMP) cyclohydrolase.

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Most popular questions from this chapter

How does 2-azahypoxanthine, a fungal product that stimulates plant growth, differ from guanine?

Individuals with a complete deficiency of dihydropyrimidine dehydrogenase exhibit a variety of symptoms. What compounds are likely to be present at high levels in the urine of these patients?

Calculate the cost, in ATP equivalents, of synthesizing de novo

(a) IMP,

(b) AMP, and

(c) CTP.

Assume all substrates (e.g., ribose-5phosphate and glutamine) and cofactors are available.

Why does it make metabolic sense for UTP to inhibit carbamoylphosphate synthetase II, whereas ATP activates the enzyme?

Describe how free purines are converted back to nucleotides.
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