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Chapter 23: Q1CP (page 808)

List the starting materials and cofactors required for IMP biosynthesis.

Short Answer

Expert verified

The starting material -D-ribose-5-phosphate, and eleven cofactors are used in the biosynthesis of inosine monophosphate (IMP).

Step by step solution

01

Starting materials required for the biosynthesis of inosine monophosphate (IMP).

The inosine monophosphate (IMP) is the purine derivative of the base hypoxanthine. The starting material of the inosine monophosphate (IMP) is -D-ribose-5-phosphate.

02

Cofactors.

The cofactors are non-protein compounds. They play the role of an enzyme as a catalyst and increase the reaction rate.

03

Cofactors required for the biosynthesis of inosine monophosphate (IMP).

  1. Ribose phosphate pyrophosphokinase.
  2. Amidophosphoribosyl transferase.
  3. Glycinamide ribotide (GAR) synthetase.
  4. Glycinamide ribotide (GAR) transformylase.
  5. Formylglycinamidine ribotide (FGAM) synthetase.
  6. 5-Aminoimidazole ribotide (AIR) synthetase.
  7. 5-Aminoimidazole ribotide (AIR) carboxylase.
  8. 5-Aminoimidazole-4-(N-succinylocarboxamide) ribotide (SAICAR) synthetase.
  9. Adenylosuccinate lyase.
  10. 5-Aminoimidazole-4-carboxamide ribotide (AICAR) transformylase.
  11. Inosine monophosphate (IMP) cyclohydrolase.

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Most popular questions from this chapter

Describe the reactions catalyzed by nucleoside phosphorylase, adenosine deaminase, and xanthine oxidase.

What compounds are produced by the degradation of purines and pyrimidines?

Compare the pathways of purine and pyrimidine nucleotide synthesis with respect to (a) precursors, (b) energy cost, (c) acquisition of the ribose moiety, and (d) number of enzymatic steps.

Describe the production of dNTPs from their corresponding NDPs.

Which reaction of the IMP AMP pathway resembles a reaction of the urea cycle?
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