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Chapter 11: Q14P (page 359)

Wolfenden has stated that it is meaningless to distinguish between the 鈥渂inding sites鈥� and the 鈥渃atalytic sites鈥� of enzymes. Explain.

Short Answer

Expert verified

An enzyme's catalytic and binding sites cannot be distinguished because they are not different. Rather, they are similar.

Step by step solution

01

Introduction of binding sites and catalytic sites of enzymes.

An enzyme's catalytic site and binding sites are the same regions with similar properties and functions.

The binding sites of an enzyme are the specific region on the enzyme with amino acids that bind to the substrates, forming a transition state and then converting it to the product.

02

Explanation of Wolfenden statement

As per the statement of Wolfenden, the binding sites and the catalytic sites of enzymes are the same. The preferential binding of the transition state to an enzyme plays an important role in the enzyme's catalytic mechanism. Thus, the binding site of the substrate can be regarded same as the catalytic site.

Hence, 'binding sites' and 'catalytic sites of the enzyme are the same.

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