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Chapter 25: Q28P (page 915)

Explain why interstrand DNA cross-links are much more mutagenic than intrastrand cross-links.

Short Answer

Expert verified

Interstrand cross-links impede the separation of two DNA strands, which is required for replication or DNA repair.

Step by step solution

01

DNA

Deoxyribonucleic acid (DNA) is a biomolecule that contains information for proteins and other regulatory elements.It is made up of two chains or strands that are connected through hydrogen bonds.

02

Interstrand cross-links are more mutagenic than intrastrand cross-link

Interstrand cross-links involve the cross-link between two strands when an endogenous or exogenous agent attaches to the bases of both strands. Intrastrand cross-links occur in the same strand. Since the strands are not separated in the interstrand cross-link, the DNA cannot be replicated or repaired, which results in mutation.

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