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Chapter 25: 4P (page 934)

Why are there no Pol I mutants that completely lack 5'鈫�3' exonuclease activity?

Short Answer

Expert verified

There are no Pol I mutants that completely lack5'鈫�3' exonuclease activity because that would be lethal for the organism.

Step by step solution

01

5'→3'Exonuclease activity.

RNA primers are needed for the initiation of DNA replication and synthesis. In the leading strand, only one RNA primer is required, but many RNA primers are required to create Okazaki fragments for the lagging strand. Later, RNA primer is replaced by DNA fragments.The 5'鈫�3'Exonuclease activity helps in the removal of RNA primers during replication.

02

Lack of 5'→3' Exonuclease activity.

If the 5'鈫�3'exonuclease activity is absent, the RNA primers cannot be removed from the DNA strand, causing the synthesized DNA to be non-functional. The process of DNA synthesis will not occur in the absence of 5'鈫�3'exonuclease activity, making it lethal for the organism. Hence, the Pol I mutants that completely lack 5'鈫�3' exonuclease activity cannot exist.

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Most popular questions from this chapter

Give the name of the enzyme that catalyzes each of the following reactions: (a) Makes a DNA strand from a DNA template

(b) Makes a DNA strand from an RNA template

(c) Makes an RNA strand from a DNA template

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The base analog 5-bromouracil (5BU),

which sterically resembles thymine, more readily undergoes tautomerization from its keto form to its enol form than does thymine. 5BU can be incorporated into newly synthesized DNA when it pairs with adenine on the template strand. However, the enol form of 5BU pairs with guanine rather than adenine. (a) Draw the 5BU 路 G base pair. (b) What type of mutation results?

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