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Chapter 25: 4P (page 934)

Why are there no Pol I mutants that completely lack 5'鈫�3' exonuclease activity?

Short Answer

Expert verified

There are no Pol I mutants that completely lack5'鈫�3' exonuclease activity because that would be lethal for the organism.

Step by step solution

01

5'→3'Exonuclease activity.

RNA primers are needed for the initiation of DNA replication and synthesis. In the leading strand, only one RNA primer is required, but many RNA primers are required to create Okazaki fragments for the lagging strand. Later, RNA primer is replaced by DNA fragments.The 5'鈫�3'Exonuclease activity helps in the removal of RNA primers during replication.

02

Lack of 5'→3' Exonuclease activity.

If the 5'鈫�3'exonuclease activity is absent, the RNA primers cannot be removed from the DNA strand, causing the synthesized DNA to be non-functional. The process of DNA synthesis will not occur in the absence of 5'鈫�3'exonuclease activity, making it lethal for the organism. Hence, the Pol I mutants that completely lack 5'鈫�3' exonuclease activity cannot exist.

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Most popular questions from this chapter

Certain sites in the E. coli chromosome are known as hot spots because they have unusually high rates of point mutations. Many of these sites contain a 5-methylcytosine residue. Explain the existence of such hot spots

Why is the observed mutation rate of E. coli 10-8to 10-10per base pair replicated, even though the error rates of PolI and Pol IIare10-6to10-7per base pair replicated?

Following DNA replication in eukaryotes, the two DNA molecules (sister chromatids) remain associated through the binding of a protein complex called cohesin. Describe cohesin鈥檚 structure and explain how it binds to DNA and how it eventually releases the DNA. What role does cohesin play in recombination?

What feature of the clamp allows it to slide along the DNA?

Why must DNA be replicated semi discontinuously?
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