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Does the herb St. John鈥檚 wort relieve major depression? Here is an excerpt from the report of one study of this issue: 鈥淒esign: Randomized, Double-Blind, Placebo-Controlled Clinical Trial.鈥 The study concluded that the difference in the effectiveness of St. John鈥檚 wort and a placebo was not statistically significant.

a. Describe the placebo effect in this context. How did the design of this experiment account for the placebo effect?

b. Explain the purpose of the random assignment.

c. Why is a double-blind design a good idea in this setting?

d. Explain what 鈥渘ot statistically significant鈥 means in this context.

Short Answer

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a. The placebo effect in this context. How did the design of this experiment account for the placebo effect is produced by a placebo, which can't be due to the placebo itself, and is thus caused by the patient's belief in that treatment. The design of the experiment accounts for the placebo effects by assigning a placebo to one of the treatment groups.

b. The purpose of the random assignment is to create two groups of subjects that are about the same at the beginning of the experiment.

c. A double-blind design is a good idea in this setting so as to know what treatment is given.

d. The difference in improvement between the two groups was not large enough to rule out potential chance variation resulting from random assignment of the variables.

Step by step solution

01

Part (a) step 1: Given Information

We need to describe the placebo effect in this context. How did the design of this experiment account for the placebo effect.

02

Part (a) step 2: Explanation

A placebo is something that is identical to the treatment received by the treatment group, except it contains no active ingredients.

The placebo effect is an effect produced by a placebo, which can't be due to the placebo itself, and is thus caused by the patients' belief in the treatment.

The design of the experiment accounts for the placebo effect by assigning a placebo to one of the treatment groups.

03

Part (b) step 1: Given Information

We need to explain the purpose of the random assignment.

04

Part (b) step 2: Explanation

To create two groups of subjects that are about the same at the beginning of the experiment.

This reduces bias in the conducting of the experiment.

05

Part (c) step 1: Given Information

We need to explain whether is a double-blind design a good idea in this setting.

06

Part (c) step 2: Explanation

Here,

Double-blind is when neither the patient or the experimenter know what treatment is given.

The subjects should not know which treatment they are receiving therefore that the researchers can measure how the placebo effect there is. But the researchers should also be blinded so that they can't influence how they measure the results.

07

Part (d) step 1: Given Information

We need to explain what 鈥渘ot statistically significant鈥 means in this context.

08

Part (d) step 2: Explanation

The difference in improvement between two groups was not large enough to rule out potential chance variation resulting from random assignment of the variables.

Definition of statistically significant.

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