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The probability that an individual randomly selected from a particular population has a certain disease is \({\rm{.05}}\). A diagnostic test correctly detects the presence of the disease \({\rm{98\% }}\)of the time and correctly detects the absence of the disease \({\rm{99\% }}\)of the time. If the test is applied twice, the two test results are independent, and both are positive, what is the (posterior) probability that the selected individual has the disease? (Hint: Tree diagram with first-generation branches corresponding to Disease and No Disease, and second- and third-generation branches corresponding to results of the two tests.)

Short Answer

Expert verified

The selected individual has the disease

\(\begin{array}{c}{\rm{P( disease }}\mid {\rm{ positive twice )}} \rm &=& 0{\rm{.7016}}\\ \rm &=& 70{\rm{.16\% }}\end{array}\)

Step by step solution

01

Definition of Independent Probability

If the probability of one event is unaffected by the occurrence or non-occurrence of the other, two events are said to be independent in probability. Consider the following example for a better understanding of this definition.

02

Finding the (posterior) probability that the selected individual has the disease?

Given:

\({\rm{P( disease ) = 0}}{\rm{.05}}\)

In 98 percent of cases, the disease is correctly recognised, and the test is thus positive:

\(\begin{array}{c}{\rm{P( positive}}\mid \rm disease ) &=& 98\% \\ \rm &=& 0{\rm{.98}}\end{array}\)

In 99 percent of cases, the absence of the disease is correctly recognised, and the test is consequently negative:

\(\begin{array}{c}{\rm{P( not positive}}\mid \rm no disease ) &=& 99\% \\ \rm &=& 0{\rm{.99}}\end{array}\)

03

Apply complement rule

Complement rule:

\({\rm{P(notA) = 1 - P(A)}}\)

General multiplication rule:

\(\begin{array}{c}\rm P(A and B) &=& P(A)*P(B\mid {\rm{A)}}\\ \rm &=& P(B)*P(A \mid {\rm{B)}}\end{array}\)

For discontinuous or mutually exclusive occurrences, use the following addition rule:

\({\rm{P(A or B) = P(A) + P(B)}}\)

Multiplication rule for independent events:

\({\rm{P(A and B) = P(A)*P(B)}}\)

Definition Conditional probability:

\({\rm{P(B}}\mid {\rm{A) = }}\frac{{{\rm{P(A and B)}}}}{{{\rm{P(A)}}}}\)

Use the complement rule:

\(\begin{array}{c} \rm P( No disease ) &=& 1 - P( disease ) \\ \rm &=& 1 - 0 \rm .05 &=& 0{\rm{.95}}\\{\rm{P( detect }}\mid \rm no disease ) &=& 1 - P( not positive \mid \rm no disease )\\ \rm &=& 1 - 0{\rm{.99}}\\ \rm &=& 0{\rm{.01}}\end{array}\)

04

 Step 4: Explanation of the Solution

Use the general multiplication rule:

\(\begin{array}{c}\rm P( positive and disease ) &=& P( disease )*P( positive \mid {\rm{ disease )}}\\ \rm &=& 0{\rm{.05*0}}{\rm{.98}}\\ \rm &=& 0{\rm{.049}}\end{array}\)

\(\begin{array}{c}{\rm{P}}\left( {{\rm{ positive and no disease}}} \right)\rm &=& P\left( {{\rm{no disease}}} \right){\rm{*P(positive}}\mid {\rm{no disease )}}\\ \rm &=& 0{\rm{.950}}{\rm{.01}}\\ \rm &=& 0{\rm{.0095}}\end{array}\)

Add the corresponding probabilities:

\(\begin{array}{c} \rm P( positive ) &=& P( positive and disease ) + P( positive and no disease )\\ \rm &=& 0{\rm{.049 + 0}}{\rm{.0095}}\\ \rm &=& 0{\rm{.0585}}\end{array}\)

05

Explain the probability

Because the two tests are independent, we can apply the multiplication rule to both. We're going to assume

\(\begin{array}{c}\rm P( positive twice ) &=& P( positive )*P( positive )\\ \rm &=& 0{\rm{.0585*0}}{\rm{.0585}}\\ \rm &=& 0{\rm{.00342225}}\end{array}\)

P(disease and positive twice )=P( positive and disease ) \(*\)P(positive and disease )

\(\begin{array}{c}\rm &=& 0{\rm{.049*0}}{\rm{.049}}\\\rm &=& 0{\rm{.002401}}\end{array}\)

Use the following conditional probability definition:

\(\begin{array}{c}{\rm{P( disease }}\mid \rm positive twice ) &=& \frac{{{\rm{P( disease and positive twice )}}}}{{{\rm{P( positive twice )}}}}\\ &=& \frac{{0.002401}}{{0.00342225}} \approx 0.7016\\ \rm &=& 70{\rm{.16\% }}\end{array}\)

Therefore , the selected individual has the disease

\(\begin{array}{c}{\rm{P( disease }}\mid {\rm{ positive twice )}} \rm &=& 0{\rm{.7016}}\\ \rm &=& 70{\rm{.16\% }}\end{array}\)

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