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Scientists and engineers frequently wish to compare two different techniques for measuring or determining the value of a variable. In such situations, interest centers on testing whether the mean difference in measurements is zero. The article "Evaluation of the Deuterium Dilution Technique Against the Test Weighing Procedure for the Determination of Breast Milk Intake" (Amer: J. of Clinical Nutr., \(1983: 996 - 1003\)) reports the accompanying data on amount of milk ingested by each of\(14\)randomly selected infants.

\(\begin{array}{*{20}{l}}{\;\;\;\;\;\;\;\;\;\;\;\;\;\;Infant\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;\;}\\{\;\;\;\;\;\;\;\;\;\;\;\;\;\;1\;\;\;\;\;\;\;\;\;\;\;\;2\;\;\;\;\;\;\;\;\;\;\;\;3\;\;\;\;\;\;\;\;\;\;\;\;4\;\;\;\;\;\;\;\;\;\;\;\;5}\\{D method\;\;\;\;\;\;\;\;\;\;\;1509\;\;\;\;\;1418\;\;\;\;\;1561\;\;\;\;\;1556\;\;\;\;\;2169}\\{W method\;\;\;\;\;\;\;\;\;\;1498\;\;\;\;\;1254\;\;\;\;\;1336\;\;\;\;\;1565\;\;\;\;\;2000}\\{jifference\;\;\;\;\;\;\;\;\;\;\;\;11\;\;\;\;\;\;\;\;\;\;164\;\;\;\;\;\;\;225\;\;\;\;\;\;\; - 9\;\;\;\;\;\;\;\;\;\;169}\end{array}\)

\(\begin{array}{*{20}{c}}{}&{Infant}&{}&{}&{}&{}\\{}&6&7&8&9&{10}\\{DD method}&{1760}&{1098}&{1198}&{1479}&{1281}\\{TW method}&{1318}&{1410}&{1129}&{1342}&{1124}\\{Difference}&{442}&{ - 312}&{69}&{137}&{157}\end{array}\)

\(\begin{array}{*{20}{c}}{}&{Infant}&{}&{}&{}\\{}&{11}&{12}&{13}&{14}\\{DD method}&{1414}&{1954}&{2174}&{2058}\\{TW method}&{1468}&{1604}&{1722}&{1518}\\{Difference}&{ - 54}&{350}&{452}&{540}\end{array}\)

a. Is it plausible that the population distribution of differences is normal?

b. Does it appear that the true average difference between intake values measured by the two methods is something other than zero? Determine the\(P\)-value of the test, and use it to reach a conclusion at significance level . \(05\).

Short Answer

Expert verified

Reject null hypothesis.

Step by step solution

01

Step 1:

The Infant data is given in the following table:

\(\begin{array}{*{20}{c}}i&{{\rm{ DD method, }}{x_i}}&{{\rm{ TW method, }}{y_i}}&{{\rm{ Difference, }}{d_i} = {x_i} - {y_i}}\\1&{1509}&{1498}&{11}\\2&{1418}&{1254}&{164}\\3&{1561}&{1336}&{225}\\4&{1556}&{1565}&{ - 9}\\5&{2169}&{2000}&{169}\\6&{1760}&{1318}&{442}\\7&{1098}&{1410}&{ - 312}\\8&{1198}&{1129}&{69}\\9&{1479}&{1342}&{137}\\{10}&{1281}&{1124}&{157}\\{11}&{1414}&{1468}&{ - 54}\\{12}&{1954}&{1604}&{350}\\{13}&{2174}&{1722}&{452}\\{14}&{2058}&{1518}&{540}\\{}&{}&{}&{}\end{array}\)

02

 Step 1: Mapping the graph

The normal probability plot indicated that the differences are normally distributed. It is plausible that the population distribution of differences is normal.

03

b)Step 2: Find the test statistic value

Because the experiment performed on the same\(14\)randomly selected infants, the pair\(t\)test should be used.

The Paired\(t\)Test:

When\(D = X - Y\)(difference between observations within a pair),\({\mu _D} = {\mu _1} - {\mu _2}\)

and null hypothesis

\({H_0}:{\mu _D} = {\Delta _0},\)

the test statistic value for testing the hypotheses is

\(t = \frac{{\bar d - {\Delta _0}}}{{{s_D}/\sqrt n }}\)

where \(\bar d\) and\({s_D}\) are the sample mean and the sample standard deviation of differences\({d_i}\), respectively. In order to use this test, assume that the differences \({D_i}\) are from a normal population. Depending on alternative hypothesis, the \(P\) value can be determined as the corresponding area under the \({t_{n - 1}}\)curve.

04

Find the mean and standard deviation

The hypotheses of interest are\({H_o}:{\mu _D} = 0\)versus\({H_a}:{\mu _D} \ne 0\). The value of test statistic can be obtained when the sample mean and the sample standard deviation of the differences is found.

The Sample Mean\(\bar x\)of observations\({x_1},{x_2}, \ldots ,{x_n}\)is given by

\(\bar x = \frac{{{x_1} + {x_2} + \ldots + {x_n}}}{n} = \frac{1}{n}\sum\limits_{i = 1}^n {{x_i}} \)

The sample mean\(\bar d\)for the differences is

\(\bar d = \frac{1}{{14}} \cdot (11 + 164 + \ldots + 540) = 167.2\)

The delta value is

\({\Delta _0} = 0\)

The only missing value to compute the test statistic value is the sample standard deviation of differences\({d_i}\).

The Sample Variance\({s^2}\)is

\({s^2} = \frac{1}{{n - 1}} \cdot {S_{xx}}\)

\({S_{xx}} = \sum {{{\left( {{x_i} - \bar x} \right)}^2}} = \sum {x_i^2} - \frac{1}{n} \cdot {\left( {\sum {{x_i}} } \right)^2}\)

The Sample Standard Deviation\(s\)is

\(s = \sqrt {{s^2}} = \sqrt {\frac{1}{{n - 1}} \cdot {S_{xx}}} \)

The sample variance is

\(\begin{array}{l}s_D^2 = \frac{1}{{14 - 1}} \cdot \left( {{{(11 - 167.2)}^2} + {{(164 - 167.2)}^2} + \ldots + {{(540 - 167.2)}^2}} \right)\\ = 52,080.18\end{array}\)

and the sample standard deviation\({s_D} = \sqrt {52,080.18} = 228\)

05

Find the test statistic value

The test statistic value is

\(t = \frac{{\bar d - {\Delta _0}}}{{{s_D}/\sqrt n }} = \frac{{167.2 - 0}}{{228/\sqrt {14} }} = 2.74\)

The test is two-sided where the alternative hypothesis is\({H_a}:{\mu _D} \ne 0\), therefore the\(P\)value is two times the area under the the\({t_{n - 1}} = {t_{14 - 1}} = \$ \$ {t_1}3\)curve to the right of\(|t|\)value

\(P = 2 \cdot P(T > 2.74) = 2 \cdot 0.009 = 0.018\)

where\(T\)has student distribution with\(13\)degrees of freedom, and the probability as computed using software (you can use table in the appendix of the book). At significance level\(0.05\), because

\(P = 0.018 < 0.05\)

reject null hypothesis

at given significance level. There is enough evidence to conclude that the true average difference between the values of the two methods is different than \(0.\)

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