Q 1.21. In Exercises 1.17-1.22, state wh... [FREE SOLUTION]

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Chapter 1: Q 1.21. (page 8)

In Exercises 1.17-1.22, state whether the investigation in question is an observational study or a designed experiment. Justify your answer in each case.
Heart Failure. In the paper "Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure" (New England Journal of Medicine, Vol. 350, pp. 2140-2150), M. Bristow et al. reported the results of a study of methods for treating patients who had advanced heart failure due to ischemic or nonischemic cardiomyopathies. A total of 1520 patients were randomly assigned in a 1:2:2 ratio to receive optimal pharmacologic therapy alone or in combination with either a pacemaker or a pacemaker-defibrillator combination. The patients were then observed until they died or were hospitalized for any cause.

Short Answer

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The investigation in question is a Designed Experiment.

Step by step solution

Step 1. Given information.

The given investigation is:

In the paper "Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure", M. Bristow et al. reported the results of a study of methods for treating patients who had advanced heart failure due to ischemic or nonischemic cardiomyopathies. A total of 1520 patients were randomly assigned in a 1:2:2 ratio to receive optimal pharmacologic therapy alone or in combination with either a pacemaker or a pacemaker-defibrillator combination.

The patients were then observed until they died or were hospitalized for any cause.

Step 2. State whether the given investigation is an observational study or a designed experiment.

From the given investigation:

A total of 1520 patients were randomly selected to undergo optimal pharmacologic therapy alone or in combination with a pacemaker or pacemaker-defibrillator mix in a 1.2:2 ratio. The patients were then kept under observation until they died or were admitted to the hospital for whatever reason.

This is a designed experiment, in which researchers impose treatments and controls, then observe and quantify characteristics. Experiments aiming to establish causation can be beneficial.