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In a clinical study, volunteers are tested for a gene that has been found to increase the risk for a disease. The probability that a person carries the gene is \(0.1 .\) (a) What is the probability that four or more people need to be tested to detect two with the gene? (b) What is the expected number of people to test to detect two with the gene?

Short Answer

Expert verified
(a) Probability is 0.972. (b) Expected people to test is 20.

Step by step solution

01

Define the Distribution

This problem involves finding the number of trials until 2 successes in a sequence of Bernoulli trials. This scenario is best modeled by a negative binomial distribution. A negative binomial distribution can be used when we want the probability of finding a fixed number of successes (in this case, 2 people with the gene) in Bernoulli trials.
02

Identify Parameters

For a negative binomial distribution, we need to define the following parameters: the probability of success in a single trial, denoted as \( p \), and the number of successes \( r \). Here, \( p = 0.1 \) and \( r = 2 \), as we are looking for 2 people with the gene.
03

Probability of Testing Four or More People

To find the probability that four or more people need to be tested, we calculate the complement of the probability of testing fewer than four people. Using the negative binomial formula, calculate the probability for exactly 2 and 3 trials: \[P(X = k) = \binom{k-1}{r-1} p^r (1-p)^{k-r}\] Calculate for \( k = 2 \) and \( k = 3 \), then sum these probabilities to find \( P(X < 4) \). Finally, use the complement \( P(X \geq 4) = 1 - P(X < 4) \).
04

Expected Number of Trials for Two Detections

The expected number of trials to achieve \( r \) successes in a negative binomial distribution is given by the formula \[ E(X) = \frac{r}{p} \]. Substitute \( r = 2 \) and \( p = 0.1 \) into the formula to calculate the expectation.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Bernoulli Trials
In probability and statistics, Bernoulli trials represent a series of experiments where each experiment has exactly two possible outcomes: success or failure. These trials are named after the Swiss mathematician Jacob Bernoulli. Each trial is independent, meaning the outcome of one trial does not affect the outcomes of others.
A common way to think about a Bernoulli trial is by flipping a coin, where the result can either be heads (success) or tails (failure).
Some key characteristics of Bernoulli trials include:
  • Each trial results in a binary outcome.
  • The probability of success, denoted by \( p \), remains constant for each trial.
  • The probability of failure, denoted by \( 1-p \), remains constant as well.
  • Trials are independent of each other.
Understanding Bernoulli trials is important for recognizing situations that can be modeled using simpler probability concepts, making it foundational knowledge for more complex distributions like the Negative Binomial Distribution used in this exercise.
Probability of Success
In probabilistic terms, the 'probability of success' is defined as the likelihood of a favorable outcome occurring in a Bernoulli trial. In the context of the exercise, the probability that an individual volunteer carries the gene is considered a success. This probability is denoted by \( p \), and in this case, it is given as \( p = 0.1 \).
The probability of success is crucial in determining parameters for various probability distributions. In our scenario, this affects how we calculate other probabilities and expectations:
  • The negative binomial distribution uses \( p \) to determine the probability of achieving a specified number of successes.
  • Each trial’s probability of success remains fixed across all trials, maintaining consistent calculations.
  • The cumulative probability of success over multiple trials can be determined using this fixed probability \( p \).
This probability acts as a vital parameter in setting up and solving problems that involve determining the distribution of outcomes in experiments like the one described.
Expected Number of Trials
When discussing the 'expected number of trials', we are referring to the average number of experimental attempts required to achieve a specified number of successes. This is a central concept in the Negative Binomial Distribution, used to measure real-world situations where you wish to calculate when an event will occur a specific number of times.
The expected number of trials, denoted by \( E(X) \), is calculated using the formula:\[ E(X) = \frac{r}{p} \]where \( r \) is the number of required successes, and \( p \) is the probability of success per trial.
In the given exercise, our aim is to determine how many people need to be tested on average to identify two who carry the gene. By substituting \( r = 2 \) and \( p = 0.1 \) into the formula, we compute the expected number of trials needed. This means, one can anticipate needing around 20 trials to detect two individuals with the gene. This concept helps researchers and statisticians plan and interpret experiments in a systematic way, making it a powerful tool for predicting outcomes in stochastic processes.

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Most popular questions from this chapter

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