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Chapter 18: Q 105 P (page 923)

Question: Show how lidocain, one of the most widely used injectable anesthetics, can be prepared from benzene and compounds containing no more than four carbons.

lidocain

Short Answer

Expert verified

The answer is,

Step by step solution

01

Benzene

The benzene can be used for the synthesis of organic compounds containing large substituents. The compounds like Novocain and lidocain can be synthesized from benzene using a series of chemical reactions using different reagents.

02

Explanation

The reaction for the synthesis of lidocain is as given below.

The Friedel- Crafts reaction can be done on a ring with a sulfonic acid group, because its deactivation is offset by the activating amide group. The sulfonic acid group is put on the ring to block the para position and thereby force the methyl groups to go to the ortho positions.

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Most popular questions from this chapter

An unknown compound reacts with ethyl chloride and aluminum trichloride to form a compound that has the following 1H NMR spectrum. What is thestructure of the compound?

A mixture of 0.10 mol benzene and 0.10 mol p-xylene was allowed to react with 0.10 mol nitronium ion until all the nitronium ion was gone. Two products were obtained: 0.002 mol of one and 0.098 mol of the other.

  1. What was the major product?
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