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Chapter 24: Q22P (page 1283)

Show where trypsin and chymotrypsin would cleave the following peptide.

Tyr-Ile-Gln-Arg-Leu-Gly-Phe-Lys-Asn-Trp-Phe-Gly-Ala-Lys-Gly-Gln-Gln.NH2

Short Answer

Expert verified

Trypsin is an enzyme and it breaks down protein into amino acids. It cleaves at the carboxyl side or C-terminal side of the amino acids lysine and arginine.

Cleavage sites of Trypsin

Step by step solution

01

Step-1. Action of trypsin on peptide chain:

Trypsin is an enzyme and it breaks down protein into amino acids. It cleaves at the carboxyl side or C-terminal side of the amino acids lysine and arginine.

Cleavage sites of Trypsin

02

Step-2. Action of chymotrypsin on peptide chain:

Chymotrypsin helps in breaking down protein into smaller units known as amino acids and cleaves at the carboxyl side of aromatic amino acids such as tyrosine, tryptophan, phenylalanine etc.

Cleavage sites of chymotrypsin

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Most popular questions from this chapter

Show how solid-phase peptide synthesis would be used to make Ile-Gly-Asn.
  1. Show how you would use a Strecker synthesis to make phenylalanine.
  2. Propose a mechanism for each step in the synthesis in part (a).

Draw the structure of the predominant form of

(a)Isoleucine at pH 11 (b) Proline at pH 2

(c)Arginine at pH 7 (d) Glutamic acid at pH 7

A mixture of alanine, lysine, and aspartic acid at 1). pH 6 ; 2). pH 11; 3). pH 2

Histidine is an important catalytic residue found at the active sites of many enzymes. In many cases, histidine appears to remove protons or to transfer protons from one location to another.

(a) Show which nitrogen atom of the histidine heterocycle is basic and which is not.

(b) Use resonance forms to show why the protonated form of histidine is a particularly stable cation.

(c) Show the structure that results when histidine accepts a proton on the basic nitrogen of the heterocycle and then is deprotonated on the other heterocyclic nitrogen. Explain how histidine might function as a pipeline to transfer protons between sites within an enzyme and its substrate.

Draw the electrophoretic separation of Trp, Cys, and His at pH 6.0.
See all solutions

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