Chapter 29: Q53P (page 1194)
Name each peptide using both the three-letter and one-letter abbreviations of the component amino acids.

a.

b.
Short Answer
- Gly-Asp-Glu and G-D-E.
- Ala-Gly-Arg and A-G-R.
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Chapter 29: Q53P (page 1194)
Name each peptide using both the three-letter and one-letter abbreviations of the component amino acids.

a.

b.
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Devise a synthesis of each peptide from amino acid starting materials:
(a) Leu–Val; (b) Ala–Ile–Gly.
Draw the structure of leu-enkephalin, a pentapeptide that acts as an analgesic and opiate, and has the following sequence: Tyr–Gly–Gly–Phe–Leu. (The structure of a related peptide, met-enkephalin,
appeared in Section 22.6B.)
a. Draw the structure of the tripeptide A-A-A, and label the two ionizable functional groups.
b. What is the predominant form of A-A-A at pH=1?
c. The values for the two ionizable functional groups (3.39 and 8.03) differ considerably from the values of alanine (2.35 and 9.87;see table 29.1). Account for the observed differences.
What is the structure of each amino acid at its isoelectric point: (a) alanine (b) methionine; (c)aspartic acid; (d) lysine?
The fibroin proteins found in silk fibers consist of large regions of β-pleated sheets stacked one on top of another. (a) Explain why having a glycine at every other residue allows the β-pleated sheets to stack on top of each other. (b) Why are silk fibers insoluble in water?
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