/*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} Problem 21 What is a nucleosome-free region... [FREE SOLUTION] | 91影视

91影视

Log out

Learning Materials

Features

Discover

Chapter 15: Problem 21

What is a nucleosome-free region? Where are such regions typically found in a genome? How are nucleosome-free regions thought to be functionally important?

Short Answer

Expert verified
Nucleosome-free regions are parts of the DNA that aren't wound around histones. They're typically found at the start and end of genes, specifically at promoter, terminator, and enhancer sequences. They're thought to be crucial for gene regulation as they allow binding of proteins necessary for transcription.

Step by step solution

01

Definition of a Nucleosome

A nucleosome is the fundamental unit of DNA packaging in eukaryotes. It consists of a segment of DNA wound around eight histone protein cores. This structure compacts the DNA molecule and prevents it from becoming tangled.
02

Understanding Nucleosome-Free Regions

Nucleosome-free regions (NFRs) are areas where the DNA is not wound around the histones and thus is not part of a nucleosome. They are generally found at the beginning and end of genes, that is, at promoter, terminator, and enhancer sequences, allowing for the binding of proteins necessary for transcription and regulation.
03

Functional Importance of Nucleosome-Free Regions

Nucleosome-free regions are thought to play a significant role in gene regulation. As transcription factors and other regulatory proteins need to access the DNA to bind to it, these regions provide them with this access. Therefore, they facilitate the transcription process where the DNA is transformed into RNA.

Unlock Step-by-Step Solutions & Ace Your Exams!

  • Full Textbook Solutions

    Get detailed explanations and key concepts

  • Unlimited Al creation

    Al flashcards, explanations, exams and more...

  • Ads-free access

    To over 500 millions flashcards

  • Money-back guarantee

    We refund you if you fail your exam.

Over 30 million students worldwide already upgrade their learning with 91影视!

One App. One Place for Learning.

All the tools & learning materials you need for study success - in one app.

Get started for free

Most popular questions from this chapter

An enhancer, located upstream from a gene, has the following sequence: $$ \begin{aligned} &5^{\prime}-\mathrm{GTAG}-3^{\prime} \\ &3^{\prime}-\mathrm{CATC}-5^{\prime} \end{aligned} $$ This enhancer is orientation-independent. Which of the following sequences also works as an enhancer? A. 5'-CTAC-3' \(3^{\prime}-\mathrm{GATG}-5^{\prime}\) B. \(5^{\prime}-\mathrm{GATG}-3^{\prime}\) \(3^{\prime}-\mathrm{CTAC}-5^{\prime}\) C. \(5^{\prime}-\mathrm{CATC}-3^{\prime}\) \(3^{\prime}-\mathrm{GTAG}-5^{\prime}\)

A particular drug inhibits the protein kinase that is responsible for phosphorylating the CREB protein. How would this drug affect the following events? A. The ability of the CREB protein to bind to CREs B. The ability of extracellular hormones to enhance cAMP levels C. The ability of the CREB protein to stimulate transcription D. The ability of the CREB protein to dimerize

Let's suppose a mutation in the glucocorticoid receptor does not prevent the binding of the glucocorticoid hormone to the protein but prevents the ability of the receptor to activate transcription. Make a list of all the possible defects that may explain why transcription cannot be activated.

Describe the steps that need to occur for the glucocorticoid receptor to bind to a GRE.

Briefly describe three ways that ATP-dependent chromatin-remodeling complexes may change chromatin structure.
See all solutions

Recommended explanations on Biology Textbooks

Organ Systems

Read Explanation

Bioenergetics

Read Explanation

Biological Organisms

Read Explanation

Reproduction

Read Explanation

Cells

Read Explanation

Chemistry of Life

Read Explanation
View all explanations

What do you think about this solution?

We value your feedback to improve our textbook solutions.

Study anywhere. Anytime. Across all devices.