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Chapter 15: Problem 10

Explain how phosphorylation affects the function of the CREB protein.

Short Answer

Expert verified
Phosphorylation enhances the function of the CREB protein by facilitating its binding to cAMP response elements and recruitment of CBP, thereby leading to the upregulation of gene expression.

Step by step solution

01

Understand the Role of CREB Protein

Firstly, it needs to be established that CREB, which stands for cAMP response element-binding protein, is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements, thereby controlling the transcription of downstream genes.
02

Understanding Phosphorylation

Phosphorylation is a chemical process where a phosphate group is added to an organic molecule, in this case, CREB. This is often catalyzed by a class of enzymes known as kinases.
03

Impact of Phosphorylation on CREB

In the phosphorylated state, CREB has an enhanced capacity to bind to the cAMP response element and can therefore lead to increased transcription of the downstream genes. Specifically, once it acquires a phosphate group (becoming phosphorylated), it recruits the transcriptional coactivator CBP (CREB Binding Protein), which in term leads to the upregulation of gene expression.

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