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Question: Explain why Pro residues can occupy the N-terminal turn of anαhelix.

Short Answer

Expert verified

Due to Proline Pro residues can occupy the N-terminal turn of an α helix as they do not clash with other residues.-

Step by step solution

01

Concept Introduction

Every backbone C=Ogroup in the right-hand helix shape known as the alpha helix (α-helix) forms a hydrogen bond with the backbone group of the amino acid that is four residues earlier in the protein sequence.

02

Pro Residues occupying N-terminal turn of Helix

The pyrrolidine ring of Pro in the interior of anα helix sterically interferes with the residue one turn towards the N-terminus. Pro residues in the N-terminal turn of an helix do not clash with other residues so it can occupy the N-terminal turn of an helix.

Therefore, the major reason is Proline.

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