Chapter 6: Q25P (page 178)
Question: Explain why Pro residues can occupy the N-terminal turn of anhelix.
Short Answer
Due to Proline Pro residues can occupy the N-terminal turn of an helix as they do not clash with other residues.-
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Chapter 6: Q25P (page 178)
Question: Explain why Pro residues can occupy the N-terminal turn of anhelix.
Due to Proline Pro residues can occupy the N-terminal turn of an helix as they do not clash with other residues.-
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Describe the primary, secondary, tertiary, and quaternary structures of collagen.
Question: Experiments in mice suggest that pyro glutamylation (see Problem 19 ) increases the rate of aggregation of protein. Propose an explanation for this observation.
The genetically engineered proteins that accumulate in bacterial inclusion bodies (Fig. 5-2) form amyloid structures. Such proteins are often difficult to recover in functional form from the bacteria. Explain.
Hydrophobic residues usually appear at the first and fourth positions in the seven-residue repeats of polypeptides that form coiled coils.
(a) Why do polar or charged residues usually appear in the remaining five positions?
(b) Why is the sequence more likely than the sequence to appear in a coiled coil?
What distinguishes regular and irregular secondary structures?
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