Chapter 27: Q8P (page 1030)
The enzyme thiouridylase converts certain tRNA uridine residues to 2-thiouridine. Draw the structure of this modified nucleotide.
Short Answer
The structure of 2-thiouridine is:

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Chapter 27: Q8P (page 1030)
The enzyme thiouridylase converts certain tRNA uridine residues to 2-thiouridine. Draw the structure of this modified nucleotide.
The structure of 2-thiouridine is:

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The antibiotic paromomycin binds to a ribosome and induces the same conformational changes in 16S rRNA residues A1492 and A1493 as are induced by codon–anticodon pairing (Fig. 27-32). Propose an explanation for the antibiotic effect of paromomycin.
Which codons serve as punctuation signals?
What mechanism ensures that the ribosome translocates by exactly three nucleotides?
Why is it important for all tRNAs to have similar structures?
IleRS uses a double-sieve mechanism to accurately produce and prevent the synthesis of . Which other pairs of amino acids differ in structure by a single carbon and might have aaRSs that use a similar double-sieve proofreading mechanism?
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