Chapter 27: Q5CP (page 988)
Which codons serve as punctuation signals?
Short Answer
The initiation codons and the stop codons serve as punctuation signals.
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Chapter 27: Q5CP (page 988)
Which codons serve as punctuation signals?
The initiation codons and the stop codons serve as punctuation signals.
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What mechanism ensures that the ribosome translocates by exactly three nucleotides?
Explain the significance of the observation that peptides such as fMet-Leu-Phe "activate" the phagocytotic (particle-engulfing) functions of mammalian leukocytes (white blood cells).
Describe the similarities and differences between prokaryotic and eukaryotic ribosomes.
Summarize the role of GTP hydrolysis in promoting the efficiency of translation initiation, decoding, translocation, and chain termination.
The flu virus maximizes the use of its limited (13.5 kB) genome by using alternative translation initiation sites, overlapping reading frames, and ribosomal frameshifting. For example, part of the viral PA gene includes a rarely used CGU codon. When the ribosome pauses to translate this codon, it may slip ahead by one nucleotide and produce a polypeptide with a different C-terminal sequence. From the partial mRNA sequence shown here, determine the normal polypeptide sequence and the sequence with the frameshift.
– GAUUCCUUUCGUCAGUCCGAGA –
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