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Chapter 3: Q23P. (page 78)

Some RNA molecules are covalently modified by methylation at the N鈦秔osition in adenosine residues. Draw the structure of the modified nucleoside.

Short Answer

Expert verified

The methylated structure of adenine is N鈦�-methyladenosine.

Step by step solution

01

Introduction

Nucleotides are the chemical building units of nucleic acids. It is a three component molecule that is made up of a nitrogenous base, a sugar ribose or deoxyribose, and at least one phosphate group. The nucleotide's nitrogenous bases are a purine or pyrimidine base connected to ribose in RNA.

02

狈鈦�-惭别迟丑测濒补诲别苍辞蝉颈苍别

Adenine is a purine base. it is a bicyclic, planer molecule that forms two hydrogen bonds with thymine. The structure of N-methyladenosine, a ribonucleic acid modification, is shown (mRNA) where the N鈦� location of the adenine base is methylated.

03

Pictorial representation of 狈鈦�-惭别迟丑测濒补诲别苍辞蝉颈苍别.

Thus, the methylated structure of adenine residues of RNA molecules is N-Methyladenosine.

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Most popular questions from this chapter

Would the modified nucleoside described in Question 23 be able to participate in standard Watson鈥揅rick base pairing?

Question: Kinases are enzymes that transfer a phosphoryl group from a nucleoside triphosphate. Which of the following are valid kinase-catalyzedreactions?
(a)
(b)

Explain why increasing the NaCl concentration increases the temperature at which the two strands of DNA 鈥渕elt鈥� apart.

The pK value for N1 of adenine is 3.64, whereas the pK value for N1 of guanine is 9.50. Explain this difference.

Draw the tautomeric form of adenine.
See all solutions

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