Chapter 23: Q3P (page 828)
How does 2-azahypoxanthine, a fungal product that stimulates plant growth, differ from guanine?

Short Answer
Nitrogen is a part of the ring structure of 2-azahypoxanthine in the place of a second carbon of the guanine.

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Chapter 23: Q3P (page 828)
How does 2-azahypoxanthine, a fungal product that stimulates plant growth, differ from guanine?

Nitrogen is a part of the ring structure of 2-azahypoxanthine in the place of a second carbon of the guanine.

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Is trimethoprim a mechanism-based inhibitor of bacterial dihydrofolate reductase?
p-Aminosalicylate is used to treat infections with Mycobacterium tuberculosis. Explain how this compound blocks the production of thymidylate.

List all the enzymes of nucleotide biosynthesis that use glutamine as an amino group donor.
Why is dATP toxic to mammalian cells?
Calculate the cost, in ATP equivalents, of synthesizing de novo
(a) IMP,
(b) AMP, and
(c) CTP.
Assume all substrates (e.g., ribose-5phosphate and glutamine) and cofactors are available.
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