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Chapter 15: Q32P (page 521)

Some organisms can anaerobically convert glycerol to pyruvate. Could homolactic or alcoholic fermentation regenerate sufficient NAD鈦簍o support this pathway?

Short Answer

Expert verified

Homolactic or alcoholic fermentation is able to restore the half NAD鈦� required for the catabolism of glycerol.

Step by step solution

01

Fermentation

Glucose is transformed to two lactate molecules and two hydrogen ions in the homolactic process. Glucose is transformed to two molecules of CO鈧俛nd two molecules of ethanol during alcoholic fermentation.

02

Sufficient NAD鈦� to support glycerol to pyruvate conversion pathway

Fermentation processes produce one molecule of NAD鈦�, which is necessary for the glycolysis reaction Glyceraldehyde 3-phosphate dehydrogenase (GAPDH). GAPDH is involved in the metabolism of glycerol. It also involves the production of NADH by the glycerol phosphate dehydrogenase process.

Hence, homolactic or alcoholic fermentation can replace half of the NAD鈦簄eeded for glycerol catabolism.

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Most popular questions from this chapter

Summarize the reactions of each stage of the pathway.

The half-reactions involved in the lactate dehydrogenase (LDH) reaction and their standard reduction potentials are

Pyruvate +2H鈦�+2e鈦烩啋Lactate

狈础顿鈦�+2贬鈦�+2别鈦烩啋狈础顿贬+贬鈦�

Calculate 鈭咷 at pH 7.0 for the LDH-catalyzed reduction of pyruvate under the following conditions:

  1. [lactate]/[pyruvate]=1 and [NAD鈦篯/[NADH]=1
  2. [lactate]/[pyruvate]=160 and [NAD鈦篯/[NADH]=160
  3. [lactate]/[pyruvate]=1000 and [NAD鈦篯/[NADH]=1000
  4. Discuss the effect of the concentration ratios in Parts a-c on the direction of the reaction.

For enzymes a鈥揺 in Problem 35, identify their closest counterparts described in Chapter 15.

Why is triose phosphate isomerase considered to be catalytically perfect?

Compare homolactic and alcoholic fermentation in terms of the products and the cofactors required.
See all solutions

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