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Chapter 11: Q17P (page 359)

Design a chloromethylketone inhibitor of elastase.

Short Answer

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Tosyl-L-alanine chloromethylkeyone

Step by step solution

01

Inhibitor of digestive enzyme

Inhibitors of digestive enzymes inhibit the functional enzymes that switch off the functionality and activity of different digestive enzymes; for example, they inhibit trypsin and elastase.

02

Chloromethyl ketone inhibitor

One of the inhibitors of elastase is chloromethyl ketone inhibitor because it is a strong alkylating agent; it reacts only with His 57, thereby inactivating the enzyme elastase, which is designed as follows:

Tosyl-L-alanine chloromethylkeyone:Chloromethyl ketone inhibitor

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Most popular questions from this chapter

Predict the effect on lysozyme鈥檚 activity of mutating Glu 35 to Asp and Asp 52 to Glu.

Question: Predict the effect of mutating Asp 102 of trypsin to Asn (a) on substrate binding and (b) on catalysis.

Diagram the hydrogen-bonding interactions of the catalytic triad His鈥揕ys鈥揝er during catalysis in a hypothetical hydrolytic enzyme.

Lysozyme residues Asp 101 and Arg 114 are required for efficient catalysis, although they are located some distance from the active sites Glu 35 and Asp 52. Substituting Ala for either Asp 101 or Arg 114 does not significantly alter the enzyme鈥檚 tertiary structure, but it significantly reduces its catalytic activity. Explain.

Why are cofactors required for some enzymatic reactions?
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