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What is the ΔG°′ value for the portion of the citric acid cycle that converts malate and acetyl-CoA to citrate?

Short Answer

Expert verified

The total value ofΔGo'=-1.8 kJ mol-1.

Step by step solution

01

Conversion of malate to citrate

Citrate is formed from malate by malate dehydrogenase and citrate synthase reactions.The conversion of malate→citratereactions and their values are as follows:

Malate+NAD+→oxaloacetate+NADH+H+;△G°'1=+29.7kJmole-1

(Malate dehydrogenase reaction)

Acetyl-CoA+oxaloacetate→citrate;△G°'2=-31.5kJmol-1 (Citrate synthase reaction)

02

Total △G°'is the sum of △G°'values of malate dehydrogenase and citrate synthase reaction

Total △G°'for the conversion of malate to citrate is computed by adding the preceding values of △G°'1and△G°'2by the following formula:

Total

role="math" localid="1648637329656" △G°'=△G°'1+△G°'2=+29.7kJmol-1+(-31.5kJmol-1)=-1.8kJmol-1

Therefore, the value of△G°' is-1.8kJmol-1 .

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