/*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} Q24. Which compounds would accumulate... [FREE SOLUTION] | 91影视

91影视

Log out

Learning Materials

Features

Discover

Chapter 17: Q24. (page 586)

Which compounds would accumulate in an individual with beriberi

(caused by thiamine deficiency)?

Short Answer

Expert verified

In an individual with beriberi, pyruvate and 伪-ketoglutarate would accumulate.

Step by step solution

01

Definition of Beri Beri:

Beriberi is a disease caused by vitamin B1 (thiamine) deficiency, usually due to chronic alcoholism as ethanol inhibits thiamine uptake.

02

Accumulation of substrates in the body:

Pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase act upon pyruvate and alpha-ketoglutarate, respectively. Both these enzymes require thiamine pyrophosphate as a cofactor.In the absence of this cofactor, both the enzymes fail to continue their enzymatic action. As a result, pyruvate and alpha-ketoglutarate, which are substrates for these enzymes, would accumulate in an individual's body in Beriberi illness.

Therefore, in beriberi, pyruvate and 伪-ketoglutarate would accumulate in the body of the individual.

Unlock Step-by-Step Solutions & Ace Your Exams!

  • Full Textbook Solutions

    Get detailed explanations and key concepts

  • Unlimited Al creation

    Al flashcards, explanations, exams and more...

  • Ads-free access

    To over 500 millions flashcards

  • Money-back guarantee

    We refund you if you fail your exam.

Over 30 million students worldwide already upgrade their learning with 91影视!

One App. One Place for Learning.

All the tools & learning materials you need for study success - in one app.

Get started for free

Most popular questions from this chapter

Question: Many amino acids are broken down to intermediates of the citric acid cycle. (a) Why can鈥檛 these amino acid 鈥渞emnants鈥� be directly oxidized toCO2 by the citric acid cycle? (b) Explain why amino acids that are broken down to pyruvate can be completely oxidized by the citric acid cycle.

Question: Anaplerotic reactions permit the citric acid cycle to supply intermediates to biosynthetic pathways while maintaining the proper levels of cycle intermediates. Write the equation for the net synthesis of citrate from pyruvate.

TheCO2produced in one round of the citric acid cycle does not originate in the acetyl carbons that entered that round. If acetyl-CoA is labeled withC14at its carbonyl carbon, how many rounds of the cycle are required beforeCO214is released?

Question: Although animals cannot synthesize glucose from acetyl-CoA, if a rat is fed 14C-labeled acetate, some of the label appears in glycogen extracted from its muscles. Explain.

Photosynthetic organisms use elaborate machinery to incorporate carbon (as CO2) into glyceraldehyde-3-phosphate, which is used to synthesize glucose for later metabolism. However, one carbon is lost following glycolysis when the three-carbon pyruvate is converted to acetyl-CoA. The bacterial enzyme pyruvate-formate lyase (also known as formate C-acetyltransferase) catalyzes the reaction

Pyruvate+HSCoA鈬�acetyl-CoA+formate

How does this reaction help the cell avoid losing carbon?
See all solutions

Recommended explanations on Biology Textbooks

Heredity

Read Explanation

Astrobiological Science

Read Explanation

Substance Exchange

Read Explanation

Control of Gene Expression

Read Explanation

Genetic Information

Read Explanation

Cell Communication

Read Explanation
View all explanations

What do you think about this solution?

We value your feedback to improve our textbook solutions.

Study anywhere. Anytime. Across all devices.