/*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} Q20CP How is PKA activity regulated?... [FREE SOLUTION] | 91影视

91影视

Log out

Learning Materials

Features

Discover

Chapter 13: Q20CP (page 432)

How is PKA activity regulated?

Short Answer

Expert verified

The PKA (protein kinase A) is activated by cAMP, a second messenger that is made by adenylate cyclase on hormone-stimulated activation of a heterotrimeric G protein.

Step by step solution

01

Targets of PKA

The targets of PKA include enzymes involved in glycogen metabolism. For example, when epinephrine binds to the尾-adrenergic receptor of a muscle cell, the sequential activation of a heterotrimeric G protein, adenylate cyclase and PKA lead to the activation of glycogen phosphorylase, thereby making glucose-6-phosphate available for glycolysis in a 鈥渇ight-or-flight鈥� response.

02

PKA is activated by cAMP

The PKA is activated by cAMP.The effects of protein kinases are reversed by the activity of protein phosphatases and also regulated by phosphatases.A small change in [cAMP] results in a large change in the fraction of phosphorylated enzymes.

Unlock Step-by-Step Solutions & Ace Your Exams!

  • Full Textbook Solutions

    Get detailed explanations and key concepts

  • Unlimited Al creation

    Al flashcards, explanations, exams and more...

  • Ads-free access

    To over 500 millions flashcards

  • Money-back guarantee

    We refund you if you fail your exam.

Over 30 million students worldwide already upgrade their learning with 91影视!

One App. One Place for Learning.

All the tools & learning materials you need for study success - in one app.

Get started for free

Most popular questions from this chapter

How does calmodulin activate target proteins?

Retinoic acid (a derivative of vitamin A; Section 9-1 F) is a hormone that mediates immune system function. Would retinoic acid require a receptor on the surface of a target cell?

What is the function of a second messengersuch as cAMP?

Describe how G proteins are activated and inactivated. What protein functions as a GEF?

Which components of the phosphoinositide signaling systems are soluble and which are associated with the membrane?
See all solutions

Recommended explanations on Biology Textbooks

Biology Experiments

Read Explanation

Cells

Read Explanation

Cell Cycle

Read Explanation

Reproduction

Read Explanation

Plant Biology

Read Explanation

Heredity

Read Explanation
View all explanations

What do you think about this solution?

We value your feedback to improve our textbook solutions.

Study anywhere. Anytime. Across all devices.