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Chapter 13: Q25CP (page 439)

Which components of the phosphoinositide signaling systems are soluble and which are associated with the membrane?

Short Answer

Expert verified

In the phosphoinositide signaling system, IP3 is the water-soluble component, and the nonpolar DAG remains associated with the membrane.

Step by step solution

01

Hydrolysis of PIP2.

In the phosphoinositide signaling mechanism, phospholipase C (PLC) is activated by ligand binding to a cell surface receptor R via the heterotrimeric G protein Gq. PIP2 is hydrolyzed to IP3 and DAG by activated phospholipase C.

02

IP3 stimulation.

The endoplasmic reticulum's stored Ca2+ is stimulated by the water-soluble IP3, and this release of Ca2+ activates various cellular functions via the intermediary of calmodulin.

03

DAG association.

The nonpolar DAG continues to be connected to the membrane, where it stimulates protein kinase C to phosphorylate and subsequently controls the actions of several cellular proteins

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