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The coenzyme has to be changed from PMP back to the enzyme-PLP Schiff base in order to finish the catalytic cycle of the aminotransferase. As a result, amino groups from amino acids that engage in transamination events with -ketoglutarate are removed by the glutamate dehydrogenase process.

The coenzyme has to be changed from PMP back to the enzyme-PLP Schiff base in order to finish the catalytic cycle of the aminotransferase. As a result, amino groups from amino acids that engage in transamination events with -ketoglutarate are removed by the glutamate dehydrogenase process.

In a subsequent transamination event, the amino group of glutamate can be transferred to oxaloacetate, producing aspartate and regenerating -ketoglutarate. Hydrolysis of the -keto acid-PMP Schiff base yields PMP and a -keto acid.