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Chapter 21: Q5CP (page 724)

What is the advantage of the proteasomal active sites having different substrate specificities?

Short Answer

Expert verified

Signals from injured cells or other immune system cells prompt the antigen-presenting cells to produce more alternative proteasomal subunits with different substrate specificities during bacterial or viral infections.

Step by step solution

01

Active β-type subunits.

The three active -type subunits have varied substrate preferences; the 1 subunit cleaves after acidic residues, the 2 subunit cleaves after basic residues, and the 5 subunit cleaves after hydrophobic residues.

02

Degradation of cytosolic peptidase.

The three active -type subunits have varied substrate preferences; the 1 subunit cleaves after acidic residues, the 2 subunit cleaves after basic residues, and the 5 subunit cleaves after hydrophobic residues.

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